Assessment of thyroid disorders in patients with rosacea: a large case-control study

Abstract

Background The frequency of autoimmune diseases and thyroid cancer has been increasingly reported in association with rosacea. However, studies investigating thyroid diseases in rosacea are scarce with conflicting results. Objective To investigate the relationship between thyroid disorders and rosacea. Methods A large case-control study on age- and gender-matched 2091 rosacea patients and 9572 controls was conducted. Rosacea patients using the rosacea-specific ICD codes were compiled from the hospital records. Additionally, all participants were evaluated in terms of the presence of hypothyroidism and hyperthyroidism. Conditional logistic regression analysis was used to compute case-control odds ratios (OR) with 95% confidence intervals. Results The analysis comprehended 2091 rosacea patients (1546 female, 545 male; mean 48.73 ± 14.53 years) and 9572 controls (7009 female, 2563 male; mean 48.73 ± 15.1 years). Whereas the rate of hypothyroidism was significantly higher in rosacea patients (OR = 1.3, 95% CI 1.13–1.49, p < 0.001), there was no significant difference in the rate of hyperthyroidism between the groups (OR = 1.12, 95% CI 0.81–1.53, p = 0.497). Stratification for gender revealed a significant association between hypothyroidism and rosacea in females (OR = 1.27, 95% CI 1.1–1.47, p = 0.002) and males (OR = 1.58, 95% CI 1.04–2.4, p = 0.032). The frequency of hypothyroidism in rosacea patients increased towards the age range of 40–49 and then decreased, parallel with the hypothyroidism frequency of the study population. Study limitations Different subtypes and severities of rosacea were not distinguished. Conclusions Hypothyroidism may be a comorbidity of rosacea and investigation for hypothyroidism may be appropriate when evaluating rosacea patients.

“Zooming” in the association between rosacea and fibromyalgia syndrome: ıs it worth mentioning?

“…Rosacea is a common chronic inflammatory skin disease progressing with unclear pathogenesis and associated with multiple comorbidities, including neurologic, psychiatric, and rheumatologic diseases such as migraine, anxiety, depression, hypothyroidism, rheumatoid arthritis, and lupus erythematosus 3 , 4 . FMS is a clinical condition with widespread pain, usually accompanied by somatic and emotional symptoms 7 .…”

“…FMS is a clinical condition with widespread pain, usually accompanied by somatic and emotional symptoms 7 . Rosacea and FMS share similar commonalities in the chronic course, pathogenesis, association with several comorbidities, and triggering factors 3,4,7 . Both rosacea and FMS can be aggravated by emotional stress and environmental factors such as heat, cold, and light 6,7 .…”

“…Rosacea and thyroid disorders are also similar in accompanying metabolic status and inflammatory pathways. Augmented expression of inflammatory markers involving matrix metalloproteinases (MMP), particularly MMP-9, has been demonstrated in rosacea as well as in hypothyroid hormonal status in thyroidology 3 , 4 .…”

Exploring the Pathogenesis and Mechanism-Targeted Treatments of Rosacea: Previous Understanding and Updates

“…Rosacea has been associated with a number of metabolic-related disorders, including hypertension, dyslipidemia, thyroid disorders, obesity, and diabetes [ 124 , 125 , 126 , 127 , 128 , 129 ]. These observations suggest that systemic metabolic alterations may have a role in the pathogenesis of rosacea ( Figure 5 ).…”

Rosacea: skin disease or a systemic disorder?

“…zjistili vyšší riziko pro tato onemocnění jen u žen, u mužů bylo vyšší riziko jen pro revmatoidní artritidu (20). Také hypotyreóza (na podkladě autoimunitní thyreoiditidy) se u pacientů s rosaceou vyskytuje častěji (21). V literatuře jsou popisovány další autoimunitní nemoci -Sjögrenův syndrom, systémová skleróza, ankylozující spondylitida, autoimunní thyreoiditida, alopecia areata a vitiligo.…”