Analysis of cardiovascular risk and carotid intima-media thickness in patients with psoriasis

Machado, Elaine Cristina Faria Abrahão; Mendonça, José Alexandre; Arruda, Ana Carolina Belini Bazán; Nucci, Luciana Bertoldi; Santos, Marcel Alex Soares dos

doi:10.1016/j.abd.2019.07.004

Cited by 9 publications

(8 citation statements)

References 35 publications

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“…There is also a growing body of evidence about higher risk of metabolic syndrome and dyslipidemia in some skin disorders such as seborrheic dermatitis and psoriasis [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

High Incidence of Metabolic Syndrome Components in Lichen Planus Patients: A Prospective Cross-Sectional Study

Aryanian

Shirzadian

Hatami

et al. 2022

International Journal of Clinical Practice

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Background. Lichen planus (LP) is a chronic inflammatory dermatosis, involving the skin, appendages, and mucous membranes. There is a growing body of evidence about higher risk of metabolic syndrome and dyslipidemia in some dermatoses including LP. Aim. To evaluate lipid profile, leptin, and CRP status among Iranian LP patients, compared to healthy controls, and peruse the relationship between abnormal values of these parameters with the disease duration and physical characteristics of patients. Methods. 40 LP patients and 40 age- and sex-matched healthy controls were enrolled in the study. Data on weight, height, lipid profile, leptin, and CRP values were recorded and compared. Results. The mean values for leptin, CRP, and lipid profile parameters (except for HDL) were higher in patients, compared to controls. Total cholesterol level was negatively associated with disease duration in patients ( P value: 0.039, r: −0.33). Serum leptin level was positively correlated with BMI both in patients and controls ( P value: 0.037 and 0.003, respectively). In the patient group, LDL level, although insignificant, was higher in men, but HDL and leptin levels were significantly higher in women in comparison with men ( P value: 0.018). Conclusion. Screening of LP patients in regard to their lipid profile might be more reasonable in men or those who have other cardiovascular risk factors to prevent morbidity and mortality in result of developing cardiovascular events.

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“…There is also a growing body of evidence about higher risk of metabolic syndrome and dyslipidemia in some skin disorders such as seborrheic dermatitis and psoriasis [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

High Incidence of Metabolic Syndrome Components in Lichen Planus Patients: A Prospective Cross-Sectional Study

Aryanian

Shirzadian

Hatami

et al. 2022

International Journal of Clinical Practice

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“…Of the total number of patients studied at the Reference Center, 25% reported having high cholesterol and/or triglyceride and 10% of the patients were unable to inform whether they had any dyslipidemia (Table 2). In a study carried out in Campinas/Southeastern Brazil with 50 psoriatic patients, 50% of respondents had altered cholesterol and 42% had high triglyceride (ABRAHÃO- MACHADO et al, 2020). It is known that some proinflammatory cytokines involved in PsO, such as interleukin 1 (IL-1), IL-6 and TNF-a, also play important roles in dyslipidemia, which may explain the association between PsO and the development of atherosclerosis (MIAO et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

Study of nutritional parameters and physical activity in psoriasis patients attended at a reference center in Northeastern Brazil / Estudo de parâmetros nutricionais e atividade física em pacientes com psoríase atendidos em um centro de referência no Nordeste do Brasil

Torres¹,

Santos²

2021

BJDV

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Psoriasis is defined as an immune-mediated disease, which has a chronic and relapsing nature, multifactorial etiology, strong participation of genetic, immunological and environmental factors. Studies show the association of psoriasis with risk factors for cardiovascular diseases. An adequate diet combined with the practice of physical activity is capable of positively influencing the prognosis of the disease. The present study aimed to assess the nutritional status and physical activity practice of patients diagnosed with psoriasis seen at the Reference, Support and Treatment Center for Psoriasis Patients of the University Hospital Lauro Wanderley (HULW), in João Pessoa, Paraiba state from October to December 2018. Patients were evaluated by means of a semi-structured questionnaire to collect information such as identification data, skin color, family history of the disease, previous pathological history, life habits and feeding. High BMI prevailed in 80% of the patients, being 35% overweight and 45% obese. The result showed that 45% of the patients had a diagnosis of type 2 DM and 60% of SAH. When asked about the diagnosis of dyslipidemia, 25% of the patients reported having high cholesterol and/or triglyceride and 10% of the patients did not know how to report. With regard to the practice of physical activity, 65% of patients reported performing physical activities, of which 84.6% performed it at a frequency of 1 to 3 times a week and 15.4%, from 4 to 7 times. This preliminary study allowed us to identify the nutritional profile and the practice of physical activity of individuals with psoriasis treated at a Reference Center. The results showed the coexistence of psoriasis and comorbidities related to the metabolic syndrome in the majority of patients evaluated, with a predominance of obesity, systemic arterial hypertension and type 2 diabetes mellitus.

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“…Similar results have been reported from other parts of the world. [ 13 14 ] However, there is still a dearth of literature on this topic. The results showed a significant positive correlation between the severity of psoriasis and the levels of VEGF and cutaneous angiogenesis.…”

Section: Discussionmentioning

confidence: 99%

Assessing the association between psoriasis and cardiovascular ischemia: An investigation of vascular endothelial growth factor, cutaneous angiogenesis, and arterial stiffness

Mohta,

Ghiya

2023

Indian Dermatol Online J

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Background: Vascular endothelial growth factor (VEGF)-mediated angiogenesis’s role in developing psoriasis and cardiovascular events has been established. However, the interplay between the two diseases regarding this cytokine remains an understudied area. Aim and Objectives: This case–control study aimed to investigate the relationship between VEGF-mediated angiogenesis and cardiovascular ischemia in patients with psoriasis. Materials and Methods: The study included 200 clinically diagnosed treatment-naïve cases of psoriasis and 200 controls. The VEGF level, cutaneous vascularity, and cardiovascular ischemia were measured between cases and controls. Cutaneous vascularity was assessed using non-invasive imaging technique such as laser doppler imaging (LDI) and measuring skin blood flow measurement (SBFM). Cardiovascular ischemia was evaluated using noninvasive techniques by measuring carotid intima–media thickness (CIMT) and pulse-wave velocity (PWV). The arterial vasa vasorum was evaluated using ultrasound imaging. Results: The study found a significant correlation between psoriasis severity and levels of VEGF ( P < 0.001). Cases had significantly higher CIMT and PWV levels ( P = 0.001 and <0.001, respectively). There was a significant positive correlation between the severity of psoriasis and the levels of cutaneous angiogenesis (r = 0.7, P < 0.001). Conclusion: According to this study, patients with psoriasis are at a higher risk of developing cardiovascular ischemia due to excessive angiogenesis associated with the condition. VEGF plays a key role in atheroma formation in psoriasis patients.

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Analysis of cardiovascular risk and carotid intima-media thickness in patients with psoriasis

Cited by 9 publications

References 35 publications

High Incidence of Metabolic Syndrome Components in Lichen Planus Patients: A Prospective Cross-Sectional Study

High Incidence of Metabolic Syndrome Components in Lichen Planus Patients: A Prospective Cross-Sectional Study

Study of nutritional parameters and physical activity in psoriasis patients attended at a reference center in Northeastern Brazil / Estudo de parâmetros nutricionais e atividade física em pacientes com psoríase atendidos em um centro de referência no Nordeste do Brasil

Assessing the association between psoriasis and cardiovascular ischemia: An investigation of vascular endothelial growth factor, cutaneous angiogenesis, and arterial stiffness

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