High Incidence of Metabolic Syndrome Components in Lichen Planus Patients: A Prospective Cross-Sectional Study

Aryanian, Zeinab; Shirzadian, Azar; Hatami, Parvaneh; Dadras, Hadiyeh

doi:10.1155/2022/7184678

Cited by 7 publications

(6 citation statements)

References 31 publications

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“…The same pattern was reported by Kumar et al in India, as a statistically significant increased prevalence of increased low-density lipoprotein levels, low high-density lipoprotein levels, and diabetes mellitus was also observed in LP patients in their study [23]. Aryanian et al emphasized these findings, specifying the male gender as a significant contributor along the side of LP [24]. Ilves et al supported the association between these dyslipidemias and LP and their association with cardiovascular disease risk [22].…”

Section: Resultssupporting

confidence: 79%

“…Many reports have found discrepancies in blood parameters in LP patients compared to healthy subjects; Diabetes mellitus, Dyslipidemias, metabolic syndrome, vitamin D deficiency, hypothyroidism, Hepatitis C virus, and autoimmune disease were found to be associated with LP [20][21][22][23][24][25]. Nevertheless, the evidence regarding LP comorbidities is growing; hence, this study was conducted to evaluate the blood profile and comorbidities of LP patients in Jordan.…”

Section: Introductionmentioning

confidence: 99%

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Comorbid diseases in patients with lichen planus in Jordan: A comparative case control Study

2023

JPTCP

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Lichen Planus (LP) is an immune mediated inflammatory skin condition characterized by the presence of pruritic purplish papular rash. We aimed to assess comorbid conditions such as diabetes mellitus, dyslipidemias, metabolic syndrome, vitamin D deficiency, hypothyroidism, hepatitis C virus, and autoimmune disease in lichen planus patients in Jordan. A case-control study was conducted among 102 cases with age and gender-matched 102 controls. A thorough clinical exam and blood testing of fasting blood glucose, lipid profile, Vitamin D and B12, thyroid function, uric acid, and hepatitis C status were done. The mean age of patients was 43.7± 16 years, and females predominated 58 (57%). The cases had higher levels of blood glucose (p-value 0.03), LDL (0.001), TG (p-value 0.001), total cholesterol (p-value 0.001), uric acid (p-value 0.001) and systolic blood pressure (p-value 0.001), and lower levels of HDL (p-value 0.001), vitamin D (p-value 0.001), and T4 (p-value 0.001) compared to controls. However, there was no significant difference regarding TSH, B12, and hepatitis C status. After adjustment of age and gender, linear regression revealed that all findings were similar. The study revealed that LP patients had significant alternations with comorbid conditions such as high blood glucose, dyslipidemias, low thyroid hormone, low vitamin D levels, low uric acid levels, and high blood pressure.

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Section: Resultssupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Comorbid diseases in patients with lichen planus in Jordan: A comparative case control Study

2023

JPTCP

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“…Notably, hypertension and diabetes were highly prevalent among our patients with LP. In several studies, dyslipidemia is associated with LP, but diabetes and hypertension are not; this may be attributed to metabolic syndrome alterations, which is a known risk factor for LP and other inflammatory dermatoses such as psoriasis 12,13 .…”

Section: Discussionmentioning

confidence: 99%

Epidemiological profile between 2020 and 2021 of patients with lichen planus treated in a tertiary hospital

Rio¹,

Lemos²,

Tavares³

et al. 2023

PJDV

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Background: Lichen planus (LP) is a chronic inflammatory dermatosis of unknown etiology that manifests in various clinical forms on the skin, oral and genital mucosa, scalp, and nails. Reports have suggested that anxiety, stress, diabetes, autoimmune diseases, drugs and genetic predisposition may be triggers of the disease. Meanwhile, the association of LP with hepatitis C virus infection remains controversial. Objectives: To analyze the epidemiological profile of patients treated in a tertiary hospital and compare our findings with those in the literature. Methods: We conducted a retrospective cross-sectional observational study of patients with lesions of histopathologically confirmed LP who were treated in a tertiary hospital from January 2020 to January 2021. Additionally, we analyzed the association of LP with comorbidities, including hepatitis C and smoking. Results: Overall, 24 patients were included in the study. Of these, 19 (79%) were women, and 13 (55%) had comorbidities, including hypertension and diabetes mellitus. Additionally, 29% of the patients were smokers. The most common forms of LP found were cutaneous (15 patients, 63%), followed by a cutaneous plus nail (four patients, 17%), cutaneous plus oral (three patients, 12%) and nail (two patients, 8%) forms. Moreover, 20/24 (83%) patients with documented serology for hepatitis C showed negative results; however, one of these patients was treated for HCV 5 years before the onset of LP. Conclusions: The present study demonstrated that LP is more prevalent in women and those with higher phototypes (Fitzpatrick > III). In addition, it has several associated comorbidities. Meanwhile, although the association of LP with hepatitis C has been reported, we did not observe this in our study. Future studies with larger sample sizes should be conducted to confirm our results.

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“…The OLP pathogenesis includes a dysregulated immune response and the initial events are still not fully understood (2). Long-term release of cytokines in chronic inflammatory conditions is thought to induce disturbances in lipid and/or carbohydrate metabolism resulting in an increase in serum triglycerides (TGs) and a decrease in high-density lipoprotein (HDL) (1,3).…”

Section: Introductionmentioning

confidence: 99%

Foot Osteomyelitis Caused by Multidrug- and Extensively Drug-Resistant Gram-Negative Bacteria

Giannitsioti

Koutserimpas

Samonis

et al. 2023

Maedica

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Background: Oral lichen planus (OLP) is a chronic inflammatory disease that affects the oral mucosa. This disorder has been suggested to be related to an impairment of lipid metabolism and profile. A number of studies indicate a higher incidence of dyslipidemia in OLP patients compared to not-affected individuals.Objectives: The aim of this study was to investigate the correlations between lipid profile alterations and clinical features of oral lichen planus.Patients and methods: A total of 52 patients diagnosed with OLP were enrolled in this study. Data regarding the demography, symptoms, severity of lesions assesed by Thongprasom score and lipid profile status were collected from the medical charts. The study group was divided into two sub-cohorts: Group 1, which included OLP patients with lipid profile within the normal range, and Group 2 comprising OLP patients with alterations of the lipid status.Results: The comparative analysis between the two groups found a statistically significant association between the lipid profile and OLP symptoms. Thus, the most frequent symptom was pain, in OLP patients with normal lipid status (Group 1), and burning, in those with altered lipid status (Group 2) (p=0.050). Moreover, the presence of symptoms was reported by a higher percentage of patients from Group 2 (75%) than Group 1 (68.25%). Patients reporting burning symptomatology showed higher triglyceride levels than those who reported pain (p=0.032). Furthermore, we found that male OLP patients have higher levels of LDL compared with female subjects (p=0.021).Conclusions: Lipid profile changes are not associated with an increased severity of OLP lesions. A statistically significant association was found between burning sensation and higher lipid profile parameters.

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High Incidence of Metabolic Syndrome Components in Lichen Planus Patients: A Prospective Cross-Sectional Study

Cited by 7 publications

References 31 publications

Comorbid diseases in patients with lichen planus in Jordan: A comparative case control Study

Comorbid diseases in patients with lichen planus in Jordan: A comparative case control Study

Epidemiological profile between 2020 and 2021 of patients with lichen planus treated in a tertiary hospital

Foot Osteomyelitis Caused by Multidrug- and Extensively Drug-Resistant Gram-Negative Bacteria

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