10-year follow-up after laparoscopic sleeve gastrectomy: Outcomes in a monocentric series

Castagneto-Gissey, Lidia; Mariolo, James Rossario Casella; Genco, Alfredo; Troisi, Alfonso; Basso, Nicola; Casella, Giovanni

doi:10.1016/j.soard.2018.06.021

Cited by 66 publications

(26 citation statements)

References 22 publications

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“…The effects of SG on GERD are rather conflicting (65). However, several studies have demonstrated that SG substantially causes de novo or a worsening of preexisting GERD, development of erosive esophagitis and hiatal hernia as evaluated by the use of endoscopy (66,67). Interestingly, no correlation was found between the presence of GERD symptoms and endoscopic findings; indeed authors demonstrated how the vast majority of patients often were asymptomatic for pyrosis, reflux or regurgitation (68).…”

Section: Bariatric/metabolic Surgery and New Onset Of Gastroesophageamentioning

confidence: 99%

“…Interestingly, no correlation was found between the presence of GERD symptoms and endoscopic findings; indeed authors demonstrated how the vast majority of patients often were asymptomatic for pyrosis, reflux or regurgitation (68). Furthermore, a peculiarity of SG is that the composition of refluxate undergoes profound modifications after surgery and is characterized by the greater presence of bile (66,67). Our previously published data on endoscopy before and after SG actually confirmed the consensual increase of bile stagnation into the esophagus, which strongly correlated with the degree of erosive esophagitis and Barrett's metaplasia (66).…”

Section: Bariatric/metabolic Surgery and New Onset Of Gastroesophageamentioning

confidence: 99%

“…Earlier investigations suggest that biliary or mixed types of gastroesophageal reflux are responsible for esophageal mucosal injury contributing to the development of Barrett's esophagus (69). Several studies actually reported a significantly elevated number of Barrett's esophagus after SG (66,67,70), reaching a prevalence as high as 18.8% 5 years after this bariatric operation (70). Barrett's esophagus is considered to be a precancerous lesion and some authors have suggested that this histological alteration might evolve to dysplasia even more rapidly after SG (66,69).…”

Section: Bariatric/metabolic Surgery and New Onset Of Gastroesophageamentioning

confidence: 99%

“…Several studies actually reported a significantly elevated number of Barrett's esophagus after SG. Barrett's esophagus is indeed a precancerous lesion and some authors have suggested that this histological alteration might evolve to dysplasia even more rapidly after this operation (66,67). Esophageal adenocarcinoma is in actual fact the most common malignancy emerging after SG and postoperative endoscopic surveillance is fundamental for early diagnosis in this group of patients (69,70,77).…”

Section: Does Gerd Contraindicate Specific Bariatric Procedures?mentioning

confidence: 99%

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Obesity Surgery and Cancer: What Are the Unanswered Questions?

et al. 2020

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Obesity has become a global epidemic with a soaring economic encumbrance due to its related morbidity and mortality. Amongst obesity-related conditions, cancer is indeed the most redoubtable. Bariatric surgery has been proven to be the most effective treatment for obesity and its associated metabolic and cardiovascular disorders. However, the understanding of whether and how bariatric surgery determines a reduction in cancer risk is limited. Obesity-related malignancies primarily include colorectal and hormone-sensitive (endometrium, breast, prostate) cancers. Additionally, esophago-gastric tumors are growing to be recognized as a new category mainly associated with post-bariatric surgery outcomes. In fact, certain types of surgical procedures have been described to induce the development and subsequent progression of pre-cancerous esophageal and gastric lesions. This emerging category is of great concern and further research is required to possibly prevent such risks. Published data has generated conflicting results. In fact, while overall cancer risk reduction was reported particularly in women, some authors showed no improvement or even increased cancer incidence. Although various studies have reported beneficial effects of surgery on risk of specific cancer development, fundamental insights into the pathogenesis of obesity-related cancer are indispensable to fully elucidate its mechanisms.

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Section: Bariatric/metabolic Surgery and New Onset Of Gastroesophageamentioning

confidence: 99%

Section: Bariatric/metabolic Surgery and New Onset Of Gastroesophageamentioning

confidence: 99%

Section: Bariatric/metabolic Surgery and New Onset Of Gastroesophageamentioning

confidence: 99%

Section: Does Gerd Contraindicate Specific Bariatric Procedures?mentioning

confidence: 99%

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Obesity Surgery and Cancer: What Are the Unanswered Questions?

et al. 2020

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“…Согласно данным проведенных исследований, после обоих видов оперативного вмешательства наблюдаются случаи как неэффективного снижения массы тела, так и повторного набора массы тела (ПНМТ) [5][6][7]. В настоящее время в литературе нет единого определения ПНМТ; большая часть исследователей считают повторным набором массы тела любую прибавку массы тела после точки надир (минимальная масса тела после оперативного вмешательства).…”

Section: обоснованиеunclassified

Dynamics of body weight and comorbidities in obese patients after sleeve gastrectomy vs. gastric bypass

et al. 2020

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Background: Bariatric surgery methods have proven to be most effective in treating obesity. Weight regain (WR) is often found after various types of bariatric surgery. The clinical significance of WR is not clearly defined. Aims: to assess the dynamics of body weight and determine the amount of clinically significant WR based on the study of carbohydrate metabolism and blood pressure in patients with obesity after performing sleeve gastrectomy (SG) and gastric bypass (GB). Materials and methods: 68 patients with obesity after SG (40) and GB (28) were observed for 3 years. Body mass index (BMI), percentage of excess BMI lost (% EBMIL), WR, glycated hemoglobin, blood pressure were evaluated. Results: A comparable efficiency (EBMIL more than 50%) of the SG and the GB was at the nadir point. %EBMIL over 50% was achieved in 78.8% of patients after SG and 80.0% of patients after GB. WR more than 15% was associated with a significant increase in systolic blood pressure. Clinically significant WR in the SG group was detected in 32.5% of patients, in the GB group in 17.2% of patients (p 0.05). Conclusion: WR of more than 15% was associated with a significant increase in systolic blood pressure in patients with obesity after SG and GB, which makes it possible to consider WR of more than 15% clinically significant. A clinically significant WR 36 months after surgery was detected in 32.5% of patients after SG and 17.2% of patients after GB.

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