10-valent pneumococcal conjugate vaccine (PCV10) decreases metabolic activity but not nasopharyngeal carriage of Streptococcus pneumoniae and Haemophilus influenzae

Co-carriage of Staphylococcus aureus and Streptococcus pneumoniae among children younger than 2 years of age in a rural population in Pakistan

“…A cross-reactive antibody response or a change in the metabolic activity of commensals could be involved. 33 , 34 In a randomized controlled trial, PCV10 vaccinated children in the 11–13 months age group had lower S. aureus nasopharyngeal carriage compared to the PCV7 group. 35 A decline in the prevalence of major commensals (including S. aureus ) was seen in PCV7 vaccinated Swiss children aged less than 2 years.…”

Panel 4: Recent advances in understanding the natural history of the otitis media microbiome and its response to environmental pressures

“…The fourth study [71] found no difference in NP carriage of S. pneumoniae, S. aureus, H. influenzae or M. catarrhalis among PHiD-CV10 versus unvaccinated Brazilian children aged 6-23 months, based on 16S rRNA gene sequencing analysis and pathogen transcriptomes. The S. pneumoniae metabolic rate (species-specific RNA:DNA ratios) was higher in controls compared to vaccinated children, suggesting a pathogen-specific effect that is more subtle than that represented by carriage alone [71].…”

Upper Respiratory Tract Microbiome and Otitis Media Intertalk: Lessons from the Literature

“…Interesting data were provided by Andrade et al in a complex investigation that compared 53 children vaccinated with PCV-10 vs. 27 unvaccinated children. The strength of this study is the integrated metagenomic and transcriptomic analysis: no difference were found in nasopharyngeal carriage rates of S. pneumoniae, S. aureus, H. influenzae, or M. catarrhalis by either transcriptomic ormetagenomics analysis, but unvaccinated children had higher metabolic rates for S. pneumoniae, compared to PCV-10 vaccinated children [53].…”