10.5-kb homozygote of tumor necrosis factor-beta gene is associated with a better prognosis in gastric cancer patients

Abstract

Background. In NcoI restriction fragment length polymorphism analysis of tumor necrosis factor‐beta (TNF‐β) gene, the frequency of 10.5‐kb homozygote is low in patients with lung cancer and is associated with a better prognosis. These results should be examined in other malignancies. Methods. Using polymerase chain reaction, the authors performed NcoI restriction fragment length polymorphism analysis in 152 patients with gastric cancer, in 69 patients with benign gastric lesion, and in 141 healthy volunteers. Results. In 3‐year survival, the 10.5‐kb homozygote showed a better prognosis (87.1%) than other alleles (5.5‐kb homozygote, 52.5%; heterozygote, 79.1%), and there was a statistically significant difference between the 10.5‐kb homozygote and the 5.5‐kb homozygote. In 3‐year survival for Stages III and IV, the 10.5‐kb homozygote also showed a better prognosis (64.9%) than other alleles (5.5‐kb homozygote, 16.7%; heterozygote, 41.4%). There were statistically significant differences (10.5‐kb homozygote vs. 5.5‐kb homozygote, P < 0.01; heterozygote vs. 5.5‐kb homozygote, P < 0.05). There was a statistical difference between all patients and Stages III and IV (P < 0.05). Conclusions. The 10.5‐kb homozygote of TNF‐β gene is associated with a prolonged survival in patients with gastric cancer, as has been shown in the patients with lung cancer. Cancer 1995;75:1450‐3.

Genetic polymorphisms of TGF-?1 & TNF-? and breast cancer risk

“…Therefore, the observed moderately increased breast cancer risk associated with TNF-b G-allele containing genotypes could be attributable to decreased level of TNF-b. The present finding is supported with previous findings of the association between G-allele and lung cancer [21], gastric cancer [22], and non-Hodgkin's lymphoma [23]. In addition, the phenotype data from Wichelow et al [30] showed that those with TNF-b GG genotype secreted significantly lower levels of TNF-b than those with A-allele.…”

“…have been reported to date, the majority of epidemiological studies have focused on the association between the A252G polymorphism and a number of diseases related with inflammatory response including cancer. Several studies have investigated the association between TNF-b A252G and cancers such as lung cancer [21], gastric cancer [22], non-Hodgkin's lymphoma [23], and breast cancer [24] as well. Park et al [24] reported that GG genotype was more frequent among breast cancer cases (23.2%) than that among healthy controls (5.8%) in Korea.…”

Increased Frequency of Alleles Associated with Elevated Tumor Necrosis Factor-α Levels in Children with Kawasaki Disease

“…In contrast, allelic frequencies in Japanese patients with KD were not different from Japanese controls (A allele, 0.58 versus 0.64; p ϭ 0.51; odds ratio, 0.76; 95% CI, 0.41 to 1.31). The allelic frequencies for the white and Japanese control populations were similar to previous reports (25,31,32).…”

Role of genetic polymorphisms in tumour angiogenesis

“…The homozygous common allele genotype (TNFB*1/ TNFB*1) seems to protect against lung cancer (Shimura et al, 1994), colorectal cancer (Park et al, 1998) and breast cancer (Park et al, 2002). Studies on gastric cancer have also shown a prolonged survival in patients with this genotype (Shimura et al, 1995), whereas no association with either susceptibility or survival was demonstrated in pancreatic cancer (Barber et al, 1999).…”