Genetic polymorphisms of TGF-?1 &amp; TNF-? and breast cancer risk

Lee, Kyoung Mu; Park, Sue Kyung; Hamajima, Nobuyuki; Tajima, Kazuo; Yoo, Keun-Young; Shin, Aesun; Noh, Dong‐Young; Ahn, Sei Hyun; Hirvonen, Ari; Kang, Daehee

doi:10.1007/s10549-004-3859-2

Cited by 52 publications

(54 citation statements)

References 31 publications

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“…For instance, the frequencies of the TGFB1 2509T and TGFB1 10Pro alleles were lower than 0.4 in most Caucasian populations, [19][20][21]27 but around 0.5 in Eastern Asian populations, [15][16][17][22][23][24] including our study subjects (i.e. 0.468 for the variant 2509T allele and 0.488 for the variant 10Pro allele in controls).…”

Section: Discussionmentioning

confidence: 79%

“…Age ( Association studies on the polymorphisms of TGFB1 have been conducted previously in breast cancer, 15,[19][20][21][22][23][24][25][26] prostate cancer, 27,28 hepatocellular carcinoma 16,17 and others. [31][32][33][34][35] However, the results from these association studies remain inconsistent rather than conclusive.…”

Section: Discussionmentioning

confidence: 99%

“…12 This promoter variant may alter TGFB1 transcription activity and the binding of the transcription factor Yin Yang 1. 18 Due to its functional relevance, several molecular epidemiological studies were performed to investigate the relationship between TGFB1 polymorphisms and risk of cancers, including breast-, 15,[19][20][21][22][23][24][25][26] prostate- 27,28 and hepatocellularcarcinoma. 16,17 However, to date no studies have focused on gastric cancer in Chinese population.…”

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confidence: 99%

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Variant alleles of TGFB1 and TGFBR2 are associated with a decreased risk of gastric cancer in a Chinese population

Jin

Wang

Chen

et al. 2006

Intl Journal of Cancer

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Growing evidence suggests that the transforming growth factor b (TGF-b) signaling pathway occupies a central position in the signaling networks that control cell growth and differentiation. TGFb1 and its receptor TGF-bRII have been correlated with the development of certain forms of cancer, including gastric cancer. We hypothesized that functional genetic variants in TGFB1 and TGFBR2 are associated with gastric cancer risk. To test this hypothesis, we genotyped C-509T and Leu10Pro polymorphisms in TGFB1 and G-875A variant in TGFBR2, using the primer-introduced restriction analysis (PIRA)-PCR assay, in a case-control study of 675 gastric cancer cases and 704 healthy controls in a Chinese population. We found that the variant alleles of the promoter polymorphisms, TGFB1 C-509T and TGFBR2 G-875A, were associated with a significantly decreased risk of gastric cancer [adjusted odds ratio (OR) 5 0.65, 95% confidence interval (CI) 5 0.52-0.82 for 2509CT/TT and adjusted OR 5 0.67, 95% CI 5 0.53-0.85 for 2875GA/AA]. Furthermore, subjects with both variant genotypes of the TGFB1 C-509T and TGFBR2 G-875A were associated with a significantly (56%) decreased risk of gastric cancer (adjusted OR 5 0.44, 95% CI 5 0.32-0.62). These findings indicate, for the first-time, that the functional variants in the promoter of TGFB1 and TGFBR2 might contribute to gastric cancer susceptibility. ' 2006 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Variant alleles of TGFB1 and TGFBR2 are associated with a decreased risk of gastric cancer in a Chinese population

Jin

Wang

Chen

et al. 2006

Intl Journal of Cancer

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“…Several genetic polymorphisms exist in the TGF-b1 gene, one of which is a T-C transition at nucleotide 29 of the coding region, resulting in a leucine to proline substitution at codon 10 (Blobe et al, 2000;Breast Cancer Association Consortium, 2006;Cox et al, 2007). This single nucleotide polymorphism (SNP) T29C, which is in strong linkage disequilibrium with another common SNP C-509T, has been studied extensively for its association with breast cancer risk and survival (Yokota et al, 2000;Goode et al, 2002;Hishida et al, 2003;Krippl et al, 2003;Ziv et al, 2003;Jin et al, 2004;Le Marchand et al, 2004;Shu et al, 2004;Kaklamani et al, 2005;Lee et al, 2005;Shin et al, 2005;Skerrett et al, 2005;Breast Cancer Association Consortium, 2006;Feigelson et al, 2006;Gonzalez-Zuloeta Ladd et al, 2007). Two studies found increased risk of breast cancer among Koreans and Dutch who carry the C allele (Lee et al, 2005;Gonzalez-Zuloeta Ladd et al, 2007), whereas two other studies showed decreased risk in relation to C genotype among Americans who were older than 65 years or Japanese who were premenopausal (Hishida et al, 2003;Ziv et al, 2003).…”

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confidence: 99%

TGF-β1 genotype and phenotype in breast cancer and their associations with IGFs and patient survival

Katsaros

et al. 2008

Br J Cancer

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Transforming growth factor-b (TGF-b)-mediated signals play complicated roles in the development and progression of breast tumour. The purposes of this study were to analyse the genotype of TGF-b1 at T29C and TGF-b1 phenotype in breast tumours, and to evaluate their associations with IGFs and clinical characteristics of breast cancer. Fresh tumour samples were collected from 348 breast cancer patients. TGF-b1 genotype and phenotype were analysed with TaqMan s and ELISA, respectively. Members of the IGF family in tumour tissue were measured with ELISA. Cox proportional hazards regression analysis was performed to assess the association of TGF-b1 and disease outcomes. Patients with the T/T (29%) genotype at T29C had the highest TGF-b1, 707.9 pg mg À1 , followed by the T/C (49%), 657.8 pg mg À1 , and C/C (22%) genotypes, 640.8 pg mg À1 , (P ¼ 0.210, T/T vs C/C and C/T). TGF-b1 concentrations were positively correlated with levels of oestrogen receptor, IGF-I, IGF-II and IGFBP-3. Survival analysis showed TGF-b1 associated with disease progression, but the association differed by disease stage. For early-stage disease, patients with the T/T genotype or high TGF-b1 had shorter overall survival compared to those without T/T or with low TGF-b1; the hazard ratios (HR) were 3.54 (95% CI: 1.21 -10.40) for genotype and 2.54 (95% CI: 1.10 -5.89) for phenotype after adjusting for age, grade, histotype and receptor status. For late-stage disease, however, the association was different. The T/T genotype was associated with lower risk of disease recurrence (HR ¼ 0.13, 95% CI: 0.02 -1.00), whereas no association was found between TGF-b1 phenotype and survival outcomes. The study suggests a complex role of TGF-b1 in breast cancer progression, which supports the finding of in vitro studies that TGF-b1 has conflicting effects on tumour growth and metastasis.

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“…Recently, TNF-α polymorphisms were not found to be associated with the risk of BC in two meta-analysis studies (Fang et al, 2010). However, the results were inconsistent and ambiguous for LTA-252 A>G polymorphism studies (the most investigated site) (Park et al, 2002;KamaliSarvestani et al, 2005;Lee et al, 2005;Gaudet et al, 2007;Kohaar et al, 2009;Pooja et al, 2010;Karakus et al, 2011). Because a modest sample size and unified ethnicity of these studies, each of them might not achieve a reliable and stable conclusion, which indicate that a meta-analysis is needed to investigate this issue.…”

Section: Introductionmentioning

confidence: 99%

The Lymphotoxin-α 252 A>G Polymorphism and Breast Cancer: A Meta-analysis

Zhou

Huang²,

Chu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Objective: The aim of this meta-analysis is to evaluate associations between LTA-252 A>G and breast cancer (BC). Methods: Electronic searches of several databases were conducted for all online publications. A total of 7 studies involving 4,625 BC patients and 4,373 controls were identified. Results: This meta-analysis showed no significant association between the LTA-252 A>G polymorphism and BC in overall or Caucasian populations. However, a positive association was found limited to Asian populations. Conclusion: Although there was no significant association found between the LTA-252 A>G polymorphism and BC overall, a positive association was found in Asian populations.

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Genetic polymorphisms of TGF-?1 & TNF-? and breast cancer risk

Abstract: The results of this study therefore suggest that polymorphisms of TGF-beta1 and TNF-beta genes may modify individual susceptibility to breast cancer in Korean women.

Cited by 52 publications

References 31 publications

Variant alleles of TGFB1 and TGFBR2 are associated with a decreased risk of gastric cancer in a Chinese population

Variant alleles of TGFB1 and TGFBR2 are associated with a decreased risk of gastric cancer in a Chinese population

TGF-β1 genotype and phenotype in breast cancer and their associations with IGFs and patient survival

The Lymphotoxin-α 252 A>G Polymorphism and Breast Cancer: A Meta-analysis

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