1-Year Results of the ZEPHYR Registry (Zilver PTX for the Femoral Artery and Proximal Popliteal Artery)

Abstract

The current study demonstrated 1-year real-world outcomes after drug-eluting stent treatment for FP lesions, including challenging ones in clinical practice. Lesion length, external elastic membrane area, and minimum stent area were independent predictors for restenosis. (Zilver PTX for the Femoral Artery and Proximal Popliteal Artery-Prospective Multicenter Registry [ZEPHYR]; UMIN000008433).

Clinical Outcomes of the Intraluminal Approach for Long Occlusive Femoropopliteal Lesions Assessed by Intravascular Ultrasound

“…Several studies revealed that the distal reference lumen/EEM CSA was useful to predict TLR after stent implantation for FP lesions 16, 18, 19) , which is consistent with our results. The results of the present study suggest that restenosis risk after EVT for long occlusive lesions with small vessel is high.…”

“…Target lesion revascularization (TLR) was defined as the need for repeated procedures (endovascular or surgical) because of a problem arising from the lesion (+1 cm proximally and distally to include edge phenomena) 6) . The definition of stent thrombosis was the same as described elsewhere 18) . The definitions of IVUS parameters followed those of a previous report 19) .…”

Reply: Inflammatory Cytokine Levels After Endovascular Therapy in Patients With Peripheral Artery Disease

“…Furthermore, previous studies have reported that female sex, dialysis, critical limb ischemia, disease severity, and outflow disease have been identified as independent risk factors for in-stent restenosis in femoral artery lesions rather than those chronic diseases. [2][3][4]7 Of course, several limitations (ie, small sample size) must be mentioned in terms of no positive relationship between change of cytokine levels and in-stent restenosis; the impact of baseline chronic diseases on the results of our study, 2 including in-stent restenosis, might be small.…”

Impact of analysis interval size on the quality of optical frequency domain imaging assessments of stent implantation for lesions of the superficial femoral artery

“…OFDI allows intravascular imaging with a greater scan depth and a faster pullback speed, thereby enabling the assessment of longer lesions in vessels with larger diameter, such as lesions of the femoropopliteal (FP) or carotid arteries . Especially, FP diseases exhibit considerably long stenosis or occlusion . Hence, OFDI could be a potential imaging modality for assessment of surrogate endpoints in clinical trials for FP lesions.…”