Worldwide, Information Technology (IT) use in healthcare systems is rapidly increasing for the purposes of realizing higher quality, and reducing overall costs. This escalation in healthcare IT use is simultaneously fueling a brisk rise in institutional demands for more Information. Associatedly, with IT proliferation and the escalation of informational demands within healthcare Systems, is an ever-present loss risk of Patient's Privacy. Therefore, all efforts undertaken to protect Privacy must effectively identify conceivable threat trajectories -against which -pathways to assure protections need exist, and to which, knowledge and resources must be mustered in a timely manner. More fundamentally, however, to identify, prevent, and safeguard against encroachments upon Privacy in healthcare, there is a need for an a priori comprehension by all in healthcare that nothing can be protected adequately if the value of that which is to be protected, and/or the consequences related to the loss -are not well understood. Yet, that which is eminently clear is, in the field of healthcare, many Medical Staff have neither the understanding, an appreciation for the importance, nor the worth of Privacy of those Patients in their care. Even with the threat of official/ legal action looming, Privacy violations and compromises of Protected Health Information (PHI) by Medical Staff occur routinely. How could Medical Staff make perverse errors in judgement regarding PatientBs Privacy so often? The aim of this article is to provide a reasonable familiarization to fundamental activities and correlated behaviors that compel risks, which are responsible for Information and Privacy Compromises. Furthermore, by way of such familiarization, necessary actions to be undertakento prevent the loss of Personal Privacy in Interoperable global healthcare venues can be suitably employed.