1 Prevention and Treatment of Non-Insulin-Dependent Diabetes Mellitus

Ivy, John L.; Zderic, Ted W.; Fogt, Donovan L.

doi:10.1249/00003677-199900270-00003

Cited by 147 publications

(122 citation statements)

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“…These findings confirm those of previous studies that found improvement in insulin sensitivity after endurance training in obese and healthy individuals (3,8,12,15). Several mechanisms have been proposed to be responsible for the increases in insulin sensitivity after exercise training (28)(29)(30)(31)(32). These include increased post-receptor insulin signalling (30), increased glucose transporter protein and mRNA (31), increased activity of glycogen syntheses and hexokinase (29), decreased release and increased clearance of free fatty acids (28), increased muscle glucose delivery and changes in muscle composition (32).…”

Section: Discussionsupporting

confidence: 92%

Effects of resistance versus endurance training on serum adiponectin and insulin resistance index

Ahmadizad

Haghighi²,

Hamedinia³

2007

European Journal of Endocrinology

104

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Purpose: The purpose of the present study was to investigate the effects of resistance and endurance training on serum adiponectin and insulin resistance index (S I ) in healthy men. Methods: Twenty-four healthy males (age, 35-48 years) participated in the study. The subjects were randomly assigned to one of three groups: endurance training group (nZ8), resistance training group (nZ8) and control group (nZ8). Blood samples were taken in fasting state from all subjects. The experimental groups performed either endurance or resistance training 3 days a week for 12 weeks. The endurance training programme included continuous running at an intensity corresponding to 75-85% of maximal heart rate, while resistance training consisted of four sets of circuit weight training for 11 stations and at an intensity corresponding to 50-60% of one-repetition maximum. The maximum numbers of repetitions in each station was 12.Results: There were significant negative correlations between serum adiponectin and body fat percentage, waist-to-hip ratio, body mass index and the insulin resistance index at baseline, whereas changes in response to training were not significantly correlated. Both endurance and resistance training resulted in a significant decrease in the S I in comparison with the control group. However, serum adiponectin did not change significantly in response to resistance and endurance training. Conclusion: Endurance and resistance training caused an improvement in insulin resistance in healthy men, but this improvement was not accompanied by increased adiponectin levels.European Journal of Endocrinology 157 625-631

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Section: Discussionsupporting

confidence: 92%

Effects of resistance versus endurance training on serum adiponectin and insulin resistance index

Ahmadizad

Haghighi²,

Hamedinia³

2007

European Journal of Endocrinology

104

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“…20 Also, the aging process itself may place elderly individuals at an even greater risk for metabolic abnormalities. 21 This has become an especially relevant issue in our current society with the rapid growth of an aging population and the corresponding increased burden on health-care resources.…”

Section: Discussionmentioning

confidence: 99%

Influence of Exercise Intensity on Abdominal Fat and Adiponectin in Elderly Adults

Coker

Williams

Kortebein

et al. 2009

Metabolic Syndrome and Related Disorders

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To examine the infl uence of moderate-intensity (50% of VO 2peak ) exercise training (MI) versus high-intensity (75% of VO 2peak ) exercise training (HI) on regional fat distribution and plasma adiponectin, we randomized 18 overweight (body mass index [BMI] = 30 ± 1 kg/m 2 ) elderly (71 ± 1 years) to HI, MI, or a control group (CON). Subjects enrolled in HI or MI completed a 12-week exercise training protocol designed to expend 1000 kcal/ week. Body composition testing was completed prior to and following the exercise training using dual energy X-ray absorptiometry and a computed tomography scan. Plasma adiponectin was measured using enzymelinked immunoassay (ELISA). VO 2peak improved in HI and MI, whereas there was no change in VO 2peak in CON. No signifi cant change in body weight, BMI, and % fat occurred in MI, HI, or CON. Although there was a significant reduction in visceral fat with HI (−39 cm 2 ), there was no change in the MI or CON groups. In addition, there was a signifi cant increase in thigh muscle attenuation in the HI group. There were no changes in thigh muscle attenuation in the MI and CON groups. Also, there was no change in plasma adiponectin in the MI, HI, or CON groups. In summary, our direct comparison of exercise intensity without weight loss promotes the effi cacy of HI in the reduction in visceral fat, even without changes in adiponectin.

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“…Achievement of optimal glycaemic control is the focus of traditional treatment. Regular exercise, both aerobic and resistance training [2][3][4], results in increased glucose uptake and insulin sensitivity [5,6] and is a primary modality used in the treatment of type 2 diabetic patients [7][8][9]. As with pharmaceutical treatment, large inter-individual responses are observed in exercise training, and are hypothesised to be dependent on genetic background [10].…”

Section: Introductionmentioning

confidence: 99%

Influence of Pro12Ala peroxisome proliferator-activated receptor γ2 polymorphism on glucose response to exercise training in type 2 diabetes

et al. 2005

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1 Prevention and Treatment of Non-Insulin-Dependent Diabetes Mellitus

Cited by 147 publications

References 0 publications

Effects of resistance versus endurance training on serum adiponectin and insulin resistance index

Effects of resistance versus endurance training on serum adiponectin and insulin resistance index

Influence of Exercise Intensity on Abdominal Fat and Adiponectin in Elderly Adults

Influence of Pro12Ala peroxisome proliferator-activated receptor γ2 polymorphism on glucose response to exercise training in type 2 diabetes

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