1-O-Alkylglycerol vesicles (Algosomes): their formation and characterization

Gopinath, D.; Devraj, Ravi; Rao, B. Ramesh; Apte, S. S.; Rambhau, D.

doi:10.1016/s0378-5173(02)00397-6

Cited by 26 publications

(11 citation statements)

References 12 publications

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“…1-O-alkylglycerols have been shown to increase the permeability of the blood-brain barrier (BBB) facilitating the delivery of antibiotics and antineoplastic drugs to the brain (Gopinath et al, 2002). Intra-arterial coadministration of the antineoplastic drug methotrexate with 1-O-pentyl-rac-glycerol to C6 rat astroglioma bearing rats greatly increased the delivery of methotrexate in the tumour brain and the surrounding brain tissue (Erdlenbruch et al, 2000).…”

Section: Biological Effectsmentioning

confidence: 99%

Ether lipids

Magnusson

Haraldsson

2011

Chemistry and Physics of Lipids

122

119

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The naturally occurring 1-O-alkyl-sn-glycerols and their methoxylated congeners, 1-O-(2'-methoxyalkyl)-sn-glycerols, are biologically active compounds, ubiquitously found in nature as diacyl glyceryl ether lipids and phosphoether lipids. The chief objective of this article is to provide a comprehensive and up to date review on such ether lipids. The occurrence and distribution of these compounds in nature are extensively reviewed, their chemical structure and molecular variety, their biosynthesis and chemical synthesis and, finally, their various biological effects are described and discussed. An unprecedented biosynthesis of the 2'-methoxylated alkylglycerols is proposed. The first synthesis of enantiopure (Z)-(2'R)-1-O-(2'-methoxyhexadec-4'-enyl)-sn-glycerol, the most prevalent 2'-methoxylated type alkylglycerol present in cartilaginous fish, is described. It was accomplished by a highly convergent five step process.

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Section: Biological Effectsmentioning

confidence: 99%

Ether lipids

Magnusson

Haraldsson

2011

Chemistry and Physics of Lipids

122

119

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“…Ascorbic acid esters are amphiphilic and delineating studies about their surface active properties and applications have been reported [13][14]. Ascorbyl palmitate (AP) is an antioxidant used in both cosmetics and food industry.…”

Section: Introductionmentioning

confidence: 99%

Effect of Process Factors on the Properties of Doxycycline Nanovesicles

Honary¹,

Zahir²

2012

Trop. J. Pharm Res

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“…7 Besides these biological activities, the amphiphilic and surface active properties of synthetic 1-O-alkylrac-glycerols have been exploited to facilitate the delivery of antibiotics and antineoplastic drugs to the brain by increasing the permeability of the bloodebrain barrier. 8 The sn-(stereospecific numbering) terminology 9 implies that the absolute configuration of the natural 1-O-alkyl-sn-glycerols is S. The most prevalent fatty hydrocarbon chains representing the O-alkyl moiety found in nature emerge from palmityl (C 16:0 ), stearyl (C 18:0 ) and oleyl (C 18:1 ) alcohols. The corresponding 1-O-alkyl-sn-glycerols 1e3 are known by their trivial names as chimyl, batyl and selachyl alcohols, named after the cartilaginous fish species they were first isolated from, i.e., sharks, chimaeras and rays, respectively.…”

Section: Introductionmentioning

confidence: 99%