(1S,2S)-2-[(S)-2,2,2-Trifluoro-1-hydroxyethyl]-1-tetralol

Abstract

The crystal structure of the title enantiopure tetralol derivative {systematic name: (1S,2S)-2-[(S)-2,2,2-trifluoro-1-hydroxyethyl]-1,2,3,4-tetrahydronaphthalen-1-ol}, C12H13F3O2, synthesized by asymmetric transfer hydrogenation, was elucidated by low-temperature single-crystal X-ray diffraction. The enantiopure compound crystallizes in the Sohncke space group P212121 with one molecule in the asymmetric unit and features intramolecular as well as intermolecular O—H...O hydrogen bonding. The absolute configuration was established from anomalous dispersion effects.

Bis(dimethoxyethane-1κ2 O,O′)pentakis(1,1,1,3,3,3-hexafluoropropan-2-olato)-2κ3 O,3κ2 O-μ-hydroxido-1:3κ2 O-μ3-oxido-1:2:3κ3 O-magnesiumdialuminium

“…(XARFED; Schaefer et al, 2013). The geometric parameters of the CF 3 groups are consistent with those reported in crystal structures of other trifluoromethylated organic compounds (Motaln et al, 2023;Radan et al, 2023).…”