1-n -Hexadecyl-3-methylimidazolium methanesulfonate and chloride salts with effective activities against Candida tropicalis biofilms

Abstract

The 1-n-hexadecyl-3-methylimidazolium methanesulfonate (C16 MImMeS) and chloride (C16 MImCl) salts are extremely effective in eliminating the viable cells of Candida tropicalis biofilms, which allows the use of much lower concentrations than with the antimicrobial of choice (chlorhexidine) in hospital practices. These findings indicate these imidazolium salts as high-potential candidates for asepsis of medical environments and materials, including implants.

Synthesis of new water-soluble ionic liquids and their antibacterial profile against gram-positive and gram-negative bacteria

“…On the other hand, biofilm-forming microorganisms have a tendency to develop by following themselves onto biotic or abiotic surfaces and thereafter onto surgical instruments, since exopolysaccharide glycocalyces provide a confluent protected biofilm [21]. Biofilm formation in infectious diseases causes serious problems in treatment, and imidazolium salts with their antimicrobial activities can have a role in preventing biofilm formation [22, 23, 24].…”

Larvicidal and residual activity of imidazolium salts againstAedes aegypti(Diptera: Culicidae)

“…Attractive physicochemical properties of IS include: high thermal stability, wide liquid temperature range, wide electrochemical window, high conductivity and ion mobility, easy recycling and tunable solubility with a wide variety of organic and inorganic compounds, and these features enable the development of a broad variety of innovative applications . In general, IS have negligible flammability and, particularly interesting for exploring larvicides with a long‐term effect, insignificant vapor pressure (volatility) …”

Assessing an imidazolium salt's performance as antifungal agent on a mouthwash formulation

“…Despite the previous knowledge of the IMS antifungal and antibiofilm activity (Bergamo et al . , ), the formulations developed in this study allowed comparing between pure a substance vs its formulation, thus expanding the knowledge for the use of these IMS as applicable pharmaceutical drugs. The C 16 MImCl concentration used both for the aqueous solution and formulations (F1 and F2) was 50 μ g ml −1 , as at this dosage it was capable of effectively inhibiting micro‐organism growth.…”

“…Moreover, the IMS activity is extremely effective for eliminating preformed C. tropicalis biofilms, using much lower concentrations than the antimicrobial of choice (chlorhexidine) for hospital practices (Bergamo et al . ).…”