1-{(<i>E</i>)-[4-Bromo-2-(trifluoromethoxy)phenyl]iminomethyl}naphthalen-2-ol

Kargılı, Hakan; Macit, Mustafa; Alpaslan, Gökhan; Büyükgüngör, Orhan; Erdönmez, Ahmet

doi:10.1107/s160053681300679x

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“…The naphthalene derivatives, NAPH1 (Akbal et al 2012b), NAPH2 (Akbal et al 2012a), NAPH3 (Kargılı et al 2013), NAPH4 (Alpaslan et al 2015), NAPH5 (Tamer et al 2014), NAPH6 (Yıldırım 2012), NAPH7 (Yıldırım et al 2016), NAPH8 (Yıldırım 2012), NAPH9 (Yıldırım 2012), NAPH10 (Pekdemir et al 2013), NAPH11 (Yıldırım 2012) and NAPH12 (Kargılı et al 2012) were synthesized, and their antioxidant, radical scavenging activities and inhibition of lipid peroxidation were evaluated in the current study (Table 1).…”

Section: Synthesis Of the Naphthalene Derivativesmentioning

confidence: 99%

Screening and Evaluation of Antioxidant Activities of Selected Naphthalene Compounds

Özen

Macit

Toka

2018

JSKM

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The antioxidant activities of twelve naphthalene compounds containing (E)-1- ((3-iodophenylimino)methyl) naphthalen-2-ol (NAPH1), (E)-1- ((3-bromophenylimino) were investigated in vitro by antioxidant activity (phosphomolybdenum assay), reducing power, H 2 O 2 scavenging activity, metal chelating effects and lipid peroxidation. Scavenging activities of the naphthalen compounds were tested against 1,1-diphenyl-2-picrylhydrazyl, hydroxyl and superoxide anion radicals. Most of them are potent antioxidant, radical superoxide anion scavengers and in vitro inhibition of lipid peroxidation. The compounds; NAPH5, NAPH10 and NAPH12 were found to exhibit promising antioxidant profiles at 10 and 50 mM concentrations. Among these, NAPH5 at higher concentration was the most active compound in inhibiting lipid peroxidation as shown in the homogenates of kidney, heart and spleen. The presented results validate that NAPH5, NAPH10 and NAPH12 can be possessed as a source of antioxidant potential and a rich source of synthetic antioxidant for medicinal or foods.

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Section: Synthesis Of the Naphthalene Derivativesmentioning

confidence: 99%

Screening and Evaluation of Antioxidant Activities of Selected Naphthalene Compounds

Özen

Macit

Toka

2018

JSKM

Self Cite

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1-{(E)-[4-Bromo-2-(trifluoromethoxy)phenyl]iminomethyl}naphthalen-2-ol

Abstract: The title compound, C18H11BrF3NO2, crystallizes in the phenol–imine tautomeric form, with a strong intramolecular O—H⋯N hydrogen bond. The dihedral angle between the naphthalene ring system and the benzene ring is 28.54 (10)°.

Cited by 1 publication

References 7 publications

Screening and Evaluation of Antioxidant Activities of Selected Naphthalene Compounds

Screening and Evaluation of Antioxidant Activities of Selected Naphthalene Compounds

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1-{(E)-[4-Bromo-2-(trifluoromethoxy)phenyl]iminomethyl}naphthalen-2-ol

Abstract: The title compound, C18H11BrF3NO2, crystallizes in the phenol–imine tautomeric form, with a strong intra­molecular O—H⋯N hydrogen bond. The dihedral angle between the naphthalene ring system and the benzene ring is 28.54 (10)°.

Cited by 1 publication

References 7 publications

Screening and Evaluation of Antioxidant Activities of Selected Naphthalene Compounds

Screening and Evaluation of Antioxidant Activities of Selected Naphthalene Compounds

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Product

Resources

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Abstract: The title compound, C18H11BrF3NO2, crystallizes in the phenol–imine tautomeric form, with a strong intramolecular O—H⋯N hydrogen bond. The dihedral angle between the naphthalene ring system and the benzene ring is 28.54 (10)°.