Screening and Evaluation of Antioxidant Activities of Selected Naphthalene Compounds

Abstract

The antioxidant activities of twelve naphthalene compounds containing (E)-1- ((3-iodophenylimino)methyl) naphthalen-2-ol (NAPH1), (E)-1- ((3-bromophenylimino) were investigated in vitro by antioxidant activity (phosphomolybdenum assay), reducing power, H 2 O 2 scavenging activity, metal chelating effects and lipid peroxidation. Scavenging activities of the naphthalen compounds were tested against 1,1-diphenyl-2-picrylhydrazyl, hydroxyl and superoxide anion radicals. Most of them are potent antioxidant, radical superoxide anion scavengers and in vitro inhibition of lipid peroxidation. The compounds; NAPH5, NAPH10 and NAPH12 were found to exhibit promising antioxidant profiles at 10 and 50 mM concentrations. Among these, NAPH5 at higher concentration was the most active compound in inhibiting lipid peroxidation as shown in the homogenates of kidney, heart and spleen. The presented results validate that NAPH5, NAPH10 and NAPH12 can be possessed as a source of antioxidant potential and a rich source of synthetic antioxidant for medicinal or foods.

Semicarbazide and thiosemicarbazide containing butylated hydroxytoluene moiety: new potential antioxidant additives for synthetic lubricating oil

“…Moreover, compounds with naphthalene ring were found in many earlier reports as potential free radical scavenger. [23][24][25] Interestingly, thiosemicarbazides with strong electron withdrawing substituent such as cyano (-CN) showed lower IC 50 value, whereas corresponding semicarbazides with electron withdrawing substituents found higher IC 50 value. The reason of this phenomenon might be attributed to the thioamide-thioimidic acid tautomerism of synthesized thiosemicarbazides.…”

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“…In addition, this research found that these produced hybrids may protect DNA against the toxic agent bleomycin. Ozen et al [72] created a Schiff-base linker in twelve albocarbon-based compounds. Several techniques were used to test these hybrids' free radical scavenging capability, including metal chelating, phosphomolybdenum, reducing power, lipid peroxidation, and H2O2 scavenging activity experiments [59][60][61][62][63][64][65][66][67][68][69][70][71].…”