1-Aminoacyl-2,3-dihydro-4(1H)-quinazolinone derivatives with choleretic and antifibrillatory activity

Abstract

Twenty four new l-aminoacyl-2,3-dihydro-4( III)-quinazolinone derivatives were prepared and evaluated for their pharmacological properties. The compounds with a cyclic amino group showed a choleretic activity. Some substances displayed also antifibrillatory and antiphlogistic activity.

Dihydroquinazolinones as Potential Antiproliferative and Tumor Inhibiting agents

“…Apart from this, dihydroquinazolinones exhibited different biological activities like antibacterial, [7] anticonvaluscent, [8] antiemetic and gastrointestinal motility enhancing agents, [9] IMPDH inhibitors, [10] antifibrillatory activity, [11] antihistaminic action, [12] antiinflammatory, [13,14] antitubercular activities, [15] potential inhibitors of SIRT1, [16] Antileishmanial agents [17] and antitumor agents [18].…”

Luotonin-A based quinazolinones cause apoptosis and senescence via HDAC inhibition and activation of tumor suppressor proteins in HeLa cells

“…The quinazolinone moiety contained in natural products (Luotonin, Rutaecarpine, Tryptanthrin, Chloroqualone, Alloqualone, etc) represents medicinally and pharmaceutically important class of compounds [23,24] because of their diverse range of biological activities such as anti-cancer, diuretic, anti-inflammatory, anticonvulsant and anti-hypertensive [25,26]. In recent years, quinazolinone embedded numerous natural products have been identified [27].…”

Synthesis of 2-aryl substituted 2,3-dihydroquinazoline-4(1H)-ones under solvent free conditions using ionic liquid as a mild and efficient catalyst

“…These are widely used in biological and pharmaceutical activities [1]. The quinazolinones display wide range of biological activities such as antitumor [2,3], antidefibrillatory [4], antidepressant [5], analgesic [6], diuretic [7], antihistamine [8], vasodilating [9], antihypertensive [10], CNS stimulant [11], tranquilizing [12] and antianxietic [13]. Some representative drug molecules having quinazoline skeleton are shown in Figure 1.…”