1, 5-Dicaffeoylquinic acid-mediated glutathione synthesis through activation of Nrf2 protects against OGD/reperfusion-induced oxidative stress in astrocytes

Xu, Chang; Xiao, Heng; Zhang, Ying; Zou, Lina; Chu, Yinghao; Chu, Xun

doi:10.1016/j.brainres.2010.05.072

Cited by 42 publications

(28 citation statements)

References 37 publications

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“…An increase in flavonoid glycosides and phenolic acids and a decrease in flavone aglycones were observed in ADC extract, compared to the extract from NW and CM (Table 4), indicating that radiation-induced mutation breeding enhanced the production of certain active compounds. For examples, apigenin ( 2 ) [17], luteolin ( 3 ) [18], luteolin-7- O - β -glucoside ( 6 ) [18], chlorogenic acid ( 8 ) [19], and 1,5-DCQA ( 10 ) [20] have exhibited their antioxidant effects by attenuating the oxidative damage thorough activation of nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway. There have also been reports that acacetin-7- O - β -glucoside ( 4 ) showed moderate DPPH radical scavenging activity [21]; however 3,5-DCQA ( 11 ) exhibited strong DPPH and ABTS radical scavenging and ferric reducing antioxidant power (FRAP) activities [22].…”

Section: Resultsmentioning

confidence: 99%

Quantification of Antioxidant Phenolic Compounds in a New Chrysanthemum Cultivar by High-Performance Liquid Chromatography with Diode Array Detection and Electrospray Ionization Mass Spectrometry

Han

Kim

et al. 2017

International Journal of Analytical Chemistry

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The flowers of Chrysanthemum morifolium Ramat. have been used as an herbal tea and in traditional medicine, and the plant has been developed to produce horticultural cultivars of various colors and shapes. In this study, a new chrysanthemum cultivar with dark purple petals (C. morifolium cv. ARTI-Dark Chocolate; ADC) was developed by radiation-induced mutation breeding of its original cultivar with purple striped white petals (C. morifolium cv. Noble Wine, NW). The phenolic profile and antioxidant property of ADC were investigated and compared with NW and the commercially available medicinal herb, C. morifolium with yellow petals (CM), in order to find a scientific support to produce a new source of natural antioxidant. Flavonoid and phenolic acid profiles of the ethanol extracts of the three flowers were analyzed by high-performance liquid chromatography-diode array detector-electrospray ionization mass spectrometry (HPLC-DAD-ESIMS), while antioxidant properties were evaluated using the 1,1-diphenyl-2-picryl-hydrazyl (DPPH) and 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging assay. Among the tested flowers, ADC possessed the strongest antioxidant capacity and the highest phenolic contents. Flavonoids (acacetin, apigenin, luteolin, acacetin-7-O-β-glucoside, apigenin-7-O-β-glucoside, luteolin-7-O-β-glucoside, and linarin) and phenolic acids (chlorogenic acid and mixture of 1,4-, 1,5-, and 3,5-dicaffeoylquinic acids) were identified and quantified.

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Section: Resultsmentioning

confidence: 99%

Quantification of Antioxidant Phenolic Compounds in a New Chrysanthemum Cultivar by High-Performance Liquid Chromatography with Diode Array Detection and Electrospray Ionization Mass Spectrometry

Han

Kim

et al. 2017

International Journal of Analytical Chemistry

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“…Concerning 1,5-dicaffeoylquinic acid, Cao et al (2010) demonstrated its protection of astrocytes from cell death in an in vitro model of ischemia/reperfusion. Recently, Xiao et al (2011) indicated the dosedependent neuro-protective mechanism of this compound against amyloid b 1-42 that induces apoptosis on neuronal culture.…”

Section: Biological Activity Of Caffeoylquinic Acidsmentioning

confidence: 98%

Artichoke: botanical, agronomical, phytochemical, and pharmacological overview

et al. 2015

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Artichoke, Cynaracardunculus, is a dietary and medicinal plant species with a long tradition of use dating back to the ancient Egyptians, Greeks, and Romans. It comprises the globe artichoke, C. cardunculus subsp. scolymus, the cultivated cardoon, C. cardunculus subsp. altilis, and the wild cardoon, C. cardunculus subsp. sylvestris. The edible part of the plant is limited to the fleshy leaves (bracts) and receptacle of a large immature inflorescence, named capitulum or head, that has been shown to be a rich source of bioactive compds. On the other hand, leaves, external bracts and stems discarded by the artichoke processing industry corresponding to about 80-85 % of the total biomass of the plant, represent a suitable potential source of food additives and nutraceuticals. Nutritional and pharmacol. properties of artichoke heads and leaves are attributed mainly to polyphenolic compds. and inulin present at high concn. Other classes of chem. compds., including flavonoids, anthocyanins, sesquiterpenes, and triterpenes have been also found in the plant at lower amts. This review, after a general historical, phytogeog., and ethnobotanical overview, summarizes the current knowledge on the phytochem. and pharmacol. properties of this plant, with special emphasis on the agronomical and nutritional importance of the plant and to the methods of anal., including the recently developed metabolomic studies. [on SciFinder(R)

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“…Electrophilic compounds have been shown to induce the activation of the Nrf2 pathway and many of them, including carnosine (Calabrese et al, 2005), tert-butylhydroquinone (Li et al, 2005), the synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate amide (Tran et al, 2008;Yang et al, 2009), sulforaphane (Soane et al, 2010), and 1,5-dicaffeoylquinic acid (Cao et al, 2010), have demonstrated in vitro cytoprotective responses against oxidative and inflammatory stress in treated neuronal cells. By using these types of compounds or genetic overexpression, the neuroprotective effects of Nrf2 pathway activation have been investigated in animal models of various neurodegenerative disorders, such as Alzheimer's disease (Dumont et al, 2009), Parkinson's disease (Jakel et al, 2007;Chen et al, 2009;Yang et al, 2009), amyotrophic lateral sclerosis (Vargas et al, 2008;Neymotin et al, 2011), and Huntington's disease (Stack et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Fumarates Promote Cytoprotection of Central Nervous System Cells against Oxidative Stress via the Nuclear Factor (Erythroid-Derived 2)-Like 2 Pathway

Scannevin

Chollate

Jung

et al. 2012

J Pharmacol Exp Ther

406

382

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Oxidative stress is central to the pathology of several neurodegenerative diseases, including multiple sclerosis, and therapeutics designed to enhance antioxidant potential could have clinical value. The objective of this study was to characterize the potential direct neuroprotective effects of dimethyl fumarate (DMF) and its primary metabolite monomethyl fumarate (MMF) on cellular resistance to oxidative damage in primary cultures of central nervous system (CNS) cells and further explore the dependence and function of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway in this process. Treatment of animals or primary cultures of CNS cells with DMF or MMF resulted in increased nuclear levels of active Nrf2, with subsequent up-regulation of canonical antioxidant target genes. DMF-dependent up-regulation of antioxidant genes in vivo was lost in mice lacking Nrf2 [Nrf2(Ϫ/Ϫ)]. DMF or MMF treatment increased cellular redox potential, glutathione, ATP levels, and mitochondrial membrane potential in a concentration-dependent manner. Treating astrocytes or neurons with DMF or MMF also significantly improved cell viability after toxic oxidative challenge in a concentration-dependent manner. This effect on viability was lost in cells that had eliminated or reduced Nrf2. These data suggest that DMF and MMF are cytoprotective for neurons and astrocytes against oxidative stress-induced cellular injury and loss, potentially via up-regulation of an Nrf2-dependent antioxidant response. These data also suggest DMF and MMF may function through improving mitochondrial function. The clinical utility of DMF in multiple sclerosis is being explored through phase III trials with BG-12, which is an oral therapeutic containing DMF as the active ingredient.

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1, 5-Dicaffeoylquinic acid-mediated glutathione synthesis through activation of Nrf2 protects against OGD/reperfusion-induced oxidative stress in astrocytes

Cited by 42 publications

References 37 publications

Quantification of Antioxidant Phenolic Compounds in a New Chrysanthemum Cultivar by High-Performance Liquid Chromatography with Diode Array Detection and Electrospray Ionization Mass Spectrometry

Quantification of Antioxidant Phenolic Compounds in a New Chrysanthemum Cultivar by High-Performance Liquid Chromatography with Diode Array Detection and Electrospray Ionization Mass Spectrometry

Artichoke: botanical, agronomical, phytochemical, and pharmacological overview

Fumarates Promote Cytoprotection of Central Nervous System Cells against Oxidative Stress via the Nuclear Factor (Erythroid-Derived 2)-Like 2 Pathway

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