1,5-Benzodiazepines. Part XII. Synthesis and biological evaluation of tricyclic and tetracyclic 1,5-benzodiazepine derivatives as nevirapine analogues

A convenient synthesis of novel [1,2,4]oxadiazolo[4,3-a][1,5]benzodiazepine derivatives

“…Furthermore, heterocyclic hydroxyimino derivatives were generally utilized as useful building blocks for the synthesis of condensed systems containing five-membered heterocyclic rings. [14][15][16][17] The structure of tetrahydro- The former publications reported the process of cyclization of hydroxyimino derivatives to [1,2,4]oxadiazolo derivatives where the starting compounds were allowed to react with phosgene in refluxing toluene. 14,15 An embodiment of this reaction has emphasized a preference for the presence of the base, mostly an organic base dissolved in an organic solvent inert in this reaction.…”

Synthesis of 1,5-Benzodiazepino and S-Triazino Incorporated Derivatives of Pyrazolo (Isoxazolo) Annulated Azacarbazoles of Medicinal Interest.

“…[3] in azacarbazoles, pyrrolo-1,4-benzodiazepines, [4] anti-HIV activity. [5] in pyrazoles and FDA approved agent-the pyridodiazepine derivative nevirapine, [6] has been hailed as a major step forward in the battle against these diseases. These features encouraged us to utilize their innate and inherent In addition to 1,5-benzodiazepine and azacarbazole, the s-triazine molecule has also formed an obvious choice in the present synthetic work because of several reasons.…”

CuI nanoparticles as a remarkable catalyst in the synthesis of benzo[b][1,5]diazepines: an eco-friendly approach

“…[1][2][3][4] In addition, some of the benzodiazepines have found as important drugs to treat some diseases such as cardiovascular disorders, cancer, diabetes and viral infection (HIV). [5][6][7][8] Some of the important 1,5-benzodiazepine structures with high medicinal activity such as, olanzapine 1 and clozapine 2 (schizophrenia treatment), 9 clobazam 3 (anxiolytic agents), 10 and 3-carbamoyl-1,5-benzodiazepine 4 (selective CCK-B antagonists as potential anxiolyticdrugs) 11 has been shown in Figure 1. Therefore, the synthesis of 1,5-benzodiazepine derivatives due to a broad range of applications have always been the most interesting fields in the organic synthesis.…”