1,4-Naphthoquinone, a pro-oxidant, ameliorated radiation induced gastro-intestinal injury through perturbation of cellular redox and activation of Nrf2 pathway

Gambhir, Lokesh

doi:10.5582/ddt.2016.01028

Cited by 11 publications

(5 citation statements)

References 45 publications

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“…The mechanism of radiation-induced GI toxicity partly results from damage due to oxidative stress and the production of ROS. 29 Membrane lipids are the major targets of ROS and the free radical chain reaction. 30 Increases in lipid peroxidation products such as MDA are indices of lipid damage.…”

Section: Discussionmentioning

confidence: 99%

Hydrogen-water ameliorates radiation-induced gastrointestinal toxicity via MyD88’s effects on the gut microbiota

Xiao

Luo

et al. 2018

Exp Mol Med

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Although radiation therapy is a cornerstone of modern management of malignancies, various side effects are inevitably linked to abdominal and pelvic cancer after radiotherapy. Radiation-mediated gastrointestinal (GI) toxicity impairs the life quality of cancer survivors and even shortens their lifespan. Hydrogen has been shown to protect against tissue injuries caused by oxidative stress and excessive inflammation, but its effect on radiation-induced intestinal injury was previously unknown. In the present study, we found that oral gavage with hydrogen-water increased the survival rate and body weight of mice exposed to total abdominal irradiation (TAI); oral gavage with hydrogen-water was also associated with an improvement in GI tract function and the epithelial integrity of the small intestine. Mechanistically, microarray analysis revealed that hydrogen-water administration upregulated miR-1968-5p levels, thus resulting in parallel downregulation of MyD88 expression in the small intestine after TAI exposure. Additionally, high-throughput sequencing showed that hydrogen-water oral gavage resulted in retention of the TAI-shifted intestinal bacterial composition in mice. Collectively, our findings suggested that hydrogen-water might be used as a potential therapeutic to alleviate intestinal injury induced by radiotherapy for abdominal and pelvic cancer in preclinical settings.

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Section: Discussionmentioning

confidence: 99%

Hydrogen-water ameliorates radiation-induced gastrointestinal toxicity via MyD88’s effects on the gut microbiota

Xiao

Luo

et al. 2018

Exp Mol Med

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“…Radiation exposure from medical diagnosis, cancer therapy, nuclear exposure, and spaces flight is a kind of physical stress that increases the oxidative pressure and leads to the disturbance of cellular redox homeostasis through increasing the production of reactive oxygen species [ 39 ]. High levels of ROS can result in further oxidative damage of DNA, lipids, and protein and induce the activation of apoptotic pathway [ 40 ], so maintenance of cellular redox homeostasis is important to maintain cell viability and normal physiological responses [ 14 ]. There were studies showing that the natural source of ginger oleoresin could protect against oxidative pressure and damages.…”

Section: Discussionmentioning

confidence: 99%

“…Radiation-induced damages are mediated directly by DNA single-strand breaks, DNA double-strands breaks, and chromosome damage and indirectly due to the production of reactive oxygen species (ROS) [ 1 , 11 – 13 ]. ROS makes a large part of contributions to radiation-induced damages, so much of the efforts in the past were made in exploring potential natural antioxidants without obvious side effects to ameliorate radiation-induced toxicities [ 14 ]. Many naturally occurring phenolic compounds, such as bioactive substances in plants, grape seed proanthocyanidins, tea polyphenol, curcumin, and ginger oleoresin, have been reported to possess antioxidant properties [ 15 – 20 ].…”

Section: Introductionmentioning

confidence: 99%

Ginger Oleoresin Alleviated γ‐Ray Irradiation‐Induced Reactive Oxygen Species via the Nrf2 Protective Response in Human Mesenchymal Stem Cells

Fang

Zhao

et al. 2017

Oxidative Medicine and Cellular Longevity

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Unplanned exposure to radiation can cause side effects on high-risk individuals; meanwhile, radiotherapies can also cause injury on normal cells and tissues surrounding the tumor. Besides the direct radiation damage, most of the ionizing radiation- (IR-) induced injuries were caused by generation of reactive oxygen species (ROS). Human mesenchymal stem cells (hMSCs), which possess self-renew and multilineage differentiation capabilities, are a critical population of cells to participate in the regeneration of IR-damaged tissues. Therefore, it is imperative to search effective radioprotectors for hMSCs. This study was to demonstrate whether natural source ginger oleoresin would mitigate IR-induced injuries in human mesenchymal stem cells (hMSCs). We demonstrated that ginger oleoresin could significantly reduce IR-induced cytotoxicity, ROS generation, and DNA strand breaks. In addition, the ROS-scavenging mechanism of ginger oleoresin was also investigated. The results showed that ginger oleoresin could induce the translocation of Nrf2 to cell nucleus and activate the expression of cytoprotective genes encoding for HO-1 and NQO-1. It suggests that ginger oleoresin has a potential role of being an effective antioxidant and radioprotective agent.

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“…mp = 155−157 °C. 1 H NMR (300 MHz, CDCl 3 ): δ = 8.01 (d,J = 8.5 HZ,1H),7.56 (d,J = 2.6 Hz,1H), 7.20 (q, J = 2.7 Hz, 1H), 4.92 (d,J = 3.4 Hz,1H),4.46 (d,J = 3.4 Hz,1H),3.94 (s,3H), 1.58 (s, 6H) ppm. 13 C NMR (75 MHz, CDCl 3 ): δ = 180.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…A series of quinone derivatives based on unique conjugated cyclic dione structures have been uncovered and investigated, including benzoquinones, naphthoquinones (NQs), and anthraquinones. Favorable biological activities of these natural quinone products are widely employed in many fields. , Though quinones, naphthoquinones especially, are certified to be capable of possessing antitumor efficacy, the exact mode of action remains an open question. Previously, the indoleamine 2,3-dioxygenase 1 (IDO1) has been identified as a potential biological target for several quinone derivatives (Figure ).…”

Section: Introductionmentioning

confidence: 99%

Palladium(II)-Catalyzed Reaction of Lawsones and Propargyl Carbonates: Construction of 2,3-Furanonaphthoquinones and Evaluation as Potential Indoleamine 2,3-Dioxygenase Inhibitors

et al. 2018

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An efficient reaction utilizing propargyl carbonates through Claisen rearrangement to synthesize furanonaphthoquinones is described. The remarkable transformation exhibits excellent functional group tolerance, affording the target furanonaphthoquinones in moderate to good yields (41-85%) under mild reaction conditions. Scaled-up preparation of the model product can make this reaction a method of choice for synthesis of furanonaphthoquinone derivatives. The resulting furanonaphthoquinones were evaluated as potential indoleamine 2,3-dioxygenase inhibitors in vitro.

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1,4-Naphthoquinone, a pro-oxidant, ameliorated radiation induced gastro-intestinal injury through perturbation of cellular redox and activation of Nrf2 pathway

Cited by 11 publications

References 45 publications

Hydrogen-water ameliorates radiation-induced gastrointestinal toxicity via MyD88’s effects on the gut microbiota

Hydrogen-water ameliorates radiation-induced gastrointestinal toxicity via MyD88’s effects on the gut microbiota

Ginger Oleoresin Alleviated γ‐Ray Irradiation‐Induced Reactive Oxygen Species via the Nrf2 Protective Response in Human Mesenchymal Stem Cells

Palladium(II)-Catalyzed Reaction of Lawsones and Propargyl Carbonates: Construction of 2,3-Furanonaphthoquinones and Evaluation as Potential Indoleamine 2,3-Dioxygenase Inhibitors

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