1,4‐Dihydropyridines—a basis for developing new drugs

Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926

“…More than 25 years after the introduction of nifedipine (1), many DHP analogs have now been synthesized and numerous second-generation commercial products have appeared on the market [2].…”

4-Aryldihydropyrimidines via the Biginelli Condensation: Aza-Analogs of Nifedipine-Type Calcium Channel Modulators

“…More than 20 years after the introduction of nifedipine (1), many DHP analogs have now been synthesized and numerous second-generation commercial products have appeared on the market (e.g. 2, 3) [2]. In recent years interest has also focused on aza-analogs such as dihydropyrimidines of type 4 (DHPMs) which show a very similar pharmacological profile to classical dihydropyridine calcium channel modulators [3][4][5][6][7][8][9].…”

1H and 13C spectral assignment of 4‐aryl‐1,4,5,6,7,8‐hexahydro‐2,7,7,5‐oxo‐quinolines 3‐substituted derivatives

“…Research on 1,4-dihydropyridine (1,4-DHP) derivatives is of current interest due to the exceptional activities they exhibit as calcium antagonists, 1 which have been skillfully used in the treatment of cardiovascular diseases. 2,3 Substitution on the 1,4-DHP ring has been widely studied 4 because of the important effects that some substituents induce on the biological properties of these systems.…”