¹H and ¹³C spectral assignment of 4‐aryl‐1,4,5,6,7,8‐hexahydro‐2,7,7,5‐oxo‐quinolines 3‐substituted derivatives

Abstract

The 1H and 13C NMR spectroscopic data for 4-aryl-1,4,5,6,7,8-hexahydro-2,7,7,5-oxo-quinoline 3-substituted derivatives have been fully assigned by the combination of one- and two dimensional experiments (DEPT, HMBC, HMQC, COSY, NOE).

NMR study of 1,4-dihydropyridine derivatives endowed with long alkyl and functionalized chains

“…These findings have been accounted for by the strong push-pull effect of the groups linked to the olefinic double bonds, similar to that previously observed in other related molecules. [8][9][10][11] The alkoxycarbonyl sp 2 -carbon (COOR or COOR 1 ) on C-3 and C-5 appears at 166-167 ppm. In compounds 1c, 2a, 3c, 4a, 5a and 6a the cyano group appears at ca.119 ppm.…”

“…These data are of interest to determine the effect that this substitution pattern has on the chemical shifts of the 1,4-DHPs ring and to complete the reference data on the previously reported related systems. 8,11…”

Complete 1H and 13C NMR assignments and Z/E‐stereoconfiguration determination of isomers of 1,4‐diketone derivatives

“…These observations can be explained by the strong push-pull effect of the groups linked to the olefinic double bonds and are consistent with similar reports. [7,8] NOESY spectra were used for the determination of Z/Estereoconfiguration of the series since NOESY experiment is a very useful method to elucidate steric configuration. NOE connectivity of H-2 with the protons of the methyl group (C-5) in NOESY spectra were observed for the compounds Ea-e, but not for the compounds Za-e. Consequently, Z-stereoconfigurational compounds in the series were successfully differentiated from the E-configurations.…”