1.318 Otoneurological Findings in Spinocerebellar Ataxia

Zeigeilboim, B.S.; Santos, R.S.; Mengelberg, Heidi; Jurkiewicz, Ari Leon; Abdulmasshi, E.M.; Teive, Hélio A.G.

doi:10.1016/s1353-8020(11)70376-5

Cited by 3 publications

(6 citation statements)

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“…The most reported symptoms by patients were also observed in several studies [22][23][24][25] . Because of its multidisciplinary clinical form, various events may occur with disease progression.…”

Section: Discussionsupporting

confidence: 63%

Vestibular findings in autosomal recessive ataxia

Zeigelboim¹,

Teive²,

Carvalho³

et al. 2013

The International Tinnitus Journal

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The most evident neurotological symptoms were dizziness, lack of coordination of movement, and imbalance when walking. Alterations in vestibular examinations occurred in 89.5% of patients, mostly in the caloric test, with a predominance of deficient central vestibular system dysfunction. This underscores the importance of the contribution of topodiagnostic labyrinthine evaluations for neurodegenerative diseases.

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Section: Discussionsupporting

confidence: 63%

Vestibular findings in autosomal recessive ataxia

Zeigelboim¹,

Teive²,

Carvalho³

et al. 2013

The International Tinnitus Journal

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“…In total, oscillopsia was reported in 56.2% of our patients with cerebellar ataxia. In previous studies, the presence of oscillopsia was reported in part of patients with Friedreich ataxia [11], SCA-3 [10] and other spinocerebellar ataxias [9], although the prevalence was lower. Zeigelboim et al examined 43 patients with SCA (SCA 2,3,4,6,7,10 and ILOCA) and described blurred vision in 11.6% [9], but they did not specify if the blurred vision was movement related.…”

Section: Discussionmentioning

confidence: 88%

“…Although oscillopsia due to the DVA impairment has been demonstrated to be a major factor affecting the quality of life in patients with compensated vestibular lesion [16] and the existence of oscillopsia has been demonstrated also in CA patients [9][10][11], to our best knowledge no systematic study of DVA has been performed in patients with progressive CA.…”

Section: Introductionmentioning

confidence: 97%

“…Peripheral vestibulopathy has been reported in many CA subtypes, particularly in patients with SCA-3, Friedreich ataxia or cerebellar ataxia with neuropathy and vestibular areflexia syndrome (CANVAS) [8][9][10][11]. Thus, it is not surprising that oscillopsia has been reported in patients with degenerative cerebellar ataxias (CA) [9,12], where it can be the consequence of vestibular impairment, but impaired modulation mechanisms of VOR or other central oculomotor impairment can contribute [12][13][14]. While oscillopsia is a subjective symptom, DVA can be objectively tested and has been considered as an indirect objective indicator of VOR function.…”

Section: Introductionmentioning

confidence: 99%

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Clinical dynamic visual acuity in patients with cerebellar ataxia and vestibulopathy

et al. 2021

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Deterioration of dynamic visual acuity (DVA) as a result of impaired vestibulo-ocular reflex (VOR) has been well described in peripheral vestibulopathies, however, changes in DVA in patients with degenerative cerebellar ataxias (CA) and its relation to VOR impairment in these patients has not yet been evaluated. Our aim was to assess the alterations of DVA in CA and to evaluate its relation to vestibular function. 32 patients with CA and 3 control groups: 13 patients with unilateral and 13 with bilateral vestibulopathy and 21 age matched healthy volunteers were examined by clinical DVA test, VOR was assessed by video Head Impulse Test and caloric irrigation. The severity of ataxia in CA was assessed by Scale for the assessment and rating of ataxia (SARA). Relationship between DVA and vestibular function in CA patients was examined by linear regressions. DVA impairment was highly prevalent in CA patients (84%) and its severity did not differ between CA and bilateral vestibulopathy patients. The severity of DVA impairment in CA was linked mainly to VOR impairment and only marginally to the degree of ataxia. However, DVA impairment was present also in CA patients without significant vestibular lesion showing that central mechanisms such as impairment of central adaptation of VOR are involved. We suggest that the evaluation of DVA should be a standard part of clinical evaluation in patients with progressive CA, as this information can help to target vestibular and oculomotor rehabilitation.

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“…The most commonly reported symptoms by patients were also observed in several other studies. [19][20][21][22] Because of the illness' multidisciplinary clinical characteristics, various events may occur with disease progression. Nacamagoe, Iwamoto, and Yoshida 23 reported that the combination of vestibular dysfunction in the presence of cerebellar atrophy can contribute significantly to the appearance of gait instability, which is part of the initial symptomatology of SCAs.…”

Section: Discussionmentioning

confidence: 99%

Otoneurological Abnormalities in Patients with Friedreich's Ataxia

Zeigelboim

Mesti²,

Fonseca

et al. 2016

Int Arch Otorhinolaryngol

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Introduction Friedreich's ataxia is a neurodegenerative disease and progressive by nature. It has autosomal recessive inheritance and early onset in most cases. Nystagmus and hearing loss (in some cases) make up some of the common symptoms seen in this disorder. Objective The objective of this study is to examine vestibular disorders in patients with Friedreich ataxia. Methods We conducted a retrospective cross-sectional study. We evaluated 30 patients with ages ranging from six to 72 years (mean age of 38.6 ( ± 14.7). The patients underwent the following procedures: anamnesis, ENT, and vestibular evaluations. Results Clinically, the patients commonly had symptoms of incoordination of movement (66.7%), gait disturbances (56.7%), and dizziness (50%). In vestibular testing, alterations were predominantly evident under caloric testing (73.4%), gaze nystagmus testing (50.1%), rotational chair testing (36.7%), and optokinetic nystagmus testing (33.4%). The presence of alterations occurred under examination in 90% of subjects, with the majority occurring in those with central vestibular dysfunction (70% of the examinations). Conclusion The most evident neurotological symptoms were incoordination of movement, gait disturbances, and dizziness. Alterations in vestibular examinations occurred in 90% of patients, mostly in the caloric test, with a predominance of deficient central vestibular system dysfunction.

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1.318 Otoneurological Findings in Spinocerebellar Ataxia

Cited by 3 publications

References 0 publications

Vestibular findings in autosomal recessive ataxia

Vestibular findings in autosomal recessive ataxia

Clinical dynamic visual acuity in patients with cerebellar ataxia and vestibulopathy

Otoneurological Abnormalities in Patients with Friedreich's Ataxia

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