Abstract:1,3,5-Triazine and its derivatives have been the epicenter of chemotherapeutic molecules due to their effective biological activities, such as antibacterial, fungicidal, antimalarial, anticancer, antiviral, antimicrobial, anti-inflammatory, antiamoebic, and antitubercular activities. The present review represents a summarized report of the crucial biological activities possessed by substituted 1,3,5-triazine derivatives, with special attention to the most potent compounds.
“…1,3,5-Triazine is an important heterocyclic pharmacophore and its ring has been extensively explored as a scaffold for the design and construction of molecules with therapeutically useful properties. 33,34 Particularly, a great deal of attention has been paid to the development of anticancer agents based on the 1,3,5-triazine skeleton. 35 Currently, a number of 1,3,5-triazine-based compounds with remarkable antitumor activities and specific target selectivity have been reported and some of them reached clinical development.…”
Polynuclear platinum(II) complexes represent a class of great prospective Pt-based antitumor drugs that may expand the antitumor spectrum and overcome the clinical problems of drug resistance and side effects of...
“…1,3,5-Triazine is an important heterocyclic pharmacophore and its ring has been extensively explored as a scaffold for the design and construction of molecules with therapeutically useful properties. 33,34 Particularly, a great deal of attention has been paid to the development of anticancer agents based on the 1,3,5-triazine skeleton. 35 Currently, a number of 1,3,5-triazine-based compounds with remarkable antitumor activities and specific target selectivity have been reported and some of them reached clinical development.…”
Polynuclear platinum(II) complexes represent a class of great prospective Pt-based antitumor drugs that may expand the antitumor spectrum and overcome the clinical problems of drug resistance and side effects of...
“…The three chloro substitutions on 2,4,6-trichloro-1,3,5-triazine have been reported to exhibit differential reaction temperature sensitivity for nucleophilic substitutions reactions, thereby facilitating the incorporation of three different nucleophilic fragment groups on the triazine ring. [23] Majeed Ganai et al [24] have published an excellent compilation of more than 20 synthetic schemes for s-triazines with high yields.…”
Triazines are six-membered privileged scaffolds that have been explored in drug discovery programs owing to their stability in biological media and robust reactivity.Their unique chemical properties have led to the exploration of the triazinecontaining molecules for multifaceted disorders like Alzheimer's disease (AD). The pathology of AD involves the interplay of multiple biochemical events such as amyloid beta-aggregation, formation of reactive oxygen species, cholinergic degradation, and metal ion dysregulation. The growing incidence of AD, coupled with the limited availability of efficacious medicines, necessitates the identification of newer therapeutic approaches. Privileged scaffolds like triazines with the potential for multiple biological effects offer excellent alternatives to the treatment of multifactorial AD. The present review describes numerous triazine-containing molecules capable of modulating single as well as multiple pathological factors involved in AD.The analysis of structural features of these molecules can provide useful insights for developing newer therapies.
“…Notably, recent studies have extensively explored the utilization of these heterocyclic cores in drug design, development, and evaluation (Figure A). − For example, Lamotrigine, featuring the 1,2,4-triazine-3,5-diamine structural motif, is an anticonvulsant medication used to cure epilepsy and the recurrence of depressive episodes in bipolar disorder; Altretamine, featuring the 1,3,5-triazine-triamine structural motif, is an antineoplastic agent for cancers; Almitrine, featuring the 1,3,5-triazine-6-piperazinyl-2,4-diamine structural motif, is a respiratory stimulant drug . Meanwhile, triazine scaffolds, especially the trisubstituted 1,3,5-triazines, are also widely present in a large number of agrochemicals as milestone herbicides for weed control, such as Atrazin, Simazin, Prometryne, and so on (Figure B) .…”
Triazines
are an important class of six-membered aromatic heterocycles
possessing three nitrogen atoms, resulting in three types of regio-isomers:
1,2,4-triazines (a-triazines), 1,2,3-triazines (v-triazines), and 1,3,5-triazines (s-triazines).
Notably, the application of triazines as cyclic aza-dienes in inverse
electron-demand Diels–Alder (IEDDA) cycloaddition reactions
has been established as a unique and powerful method in N-heterocycle synthesis, natural product preparation, and bioorthogonal
chemistry. In this review, we comprehensively summarize the advances
in the construction of these triazines via annulation and ring-expansion
reactions, especially emphasizing recent developments and challenges.
The synthetic transformations of triazines are focused on IEDDA cycloaddition
reactions, which have allowed access to a wide scope of heterocycles,
including pyridines, carbolines, azepines, pyridazines, pyrazines,
and pyrimidines. The utilization of triazine IEDDA reactions as key
steps in natural product synthesis is also discussed. More importantly,
a particular attention is paid on the bioorthogonal application of
triazines in fast click ligation with various strained alkenes and
alkynes, which opens a new opportunity for studying biomolecules in
chemical biology.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.