1,25-dihydroxyvitamin D3 impairs NF-κB activation in human naïve B cells

1,25-Dihydroxyvitamin D3(1,25-(OH)2D3) Attenuates Airway Remodeling in a Murine Model of Chronic Asthma

“…The mechanism by which 1,25-(OH) 2 D 3 mediated asthmatic airway remodeling was not fully elucidated. It has been shown that the VDR could interfere with the NF-κB p65 subunit and reduce the levels of IκBα protein, which directly results in its regulation of NF-κB activation (30)(31)(32)(33). 1,25-(OH) 2 D 3 binding to the VDR has been shown to regulate NF-κB activation and also modulate multiple biological activities both in vivo and in vitro (34)(35)(36)(37)(38)(39).…”

Vitamin D-Rich Diet in Mice Modulates Erythrocyte Survival

“…Metabolites of vitamin D further modify the physiology of nonskeletal tissues and, thus, regulate a wide array of biological functions [3,4]. 1,25(OH) 2 D 3 activates various signaling cascades via the vitamin D receptor which plays a decisive role in a myriad of cellular functions such as cell proliferation and differentiation, membrane transport, redox balance, adhesion, hemostasis and apoptosis [3][4][5][6][7]. Formation of 1,25(OH) 2 D 3 is down-regulated by fibroblast growth factor 23 (FGF23) which, in turn, requires the membrane protein Klotho as a coreceptor [8][9][10].…”

Cardiovascular risk factors, burden of disease and preventive strategies in patients with systemic lupus erythematosus: a literature review

“…A previous study [87] also highlighted the ability of 1,25(OH)2D3 to inhibit the maturation of plasma cells and class-switched memory B cells, suggesting a potential role for vitamin D in B-cell-related disorders such as SLE. Notably, 1,25(OH)2D3, inhibits NF-kB pathway and p105/p50 protein expression of human naïve B cells, by impairing nuclear translocation of p65 and consequently reducing binding of p65 to its binding site in the p105 promoter.…”