Cardiovascular risk factors, burden of disease and preventive strategies in patients with systemic lupus erythematosus: a literature review

Benvenuti, Francesco; Gatto, Mariele; Larosa, Maddalena; Iaccarino, Leonardo; Punzi, Leonardo; Doria, Andrea

doi:10.1517/14740338.2015.1073259

Cited by 24 publications

(12 citation statements)

References 95 publications

(68 reference statements)

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“…The mechanism of CVD in SLE is multifactorial. Traditional CV risk factors, such as age, hypertension, dyslipidemia, and smoking, cannot fully explain the increased CVD occurrence in SLE [5][6][7], and disease-related risk factors, such as disease activity, cumulative damage, renal involvement, inflammatory mediators, and medications, have been implicated in increasing the CV risk in SLE [8]. Recently, Seguro et al showed that SLE was associated with altered adiposity distribution and increased visceral adipose tissues (VAT) in premenopausal SLE patients, and that VAT was correlated with traditional risk factors for CVD [9].…”

Section: Introductionmentioning

confidence: 99%

Altered body composition and increased visceral adipose tissue in premenopausal and late postmenopausal patients with SLE

Shang

Zeng

et al. 2019

Clin Rheumatol

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Objective Visceral adipose tissue (VAT) is becoming a recognized cardiovascular (CV) risk factor. This study aimed to evaluate body composition, especially VAT, in systemic lupus erythematosus (SLE) and to explore the association between VAT and SLE disease-related factors. Method Ninety-eight inpatients with SLE and 108 age-and body mass index (BMI)-matched healthy controls were included. Demographic and clinical parameters were recorded. The VAT was measured by dual-energy x-ray absorptiometry. Result The mean age and disease duration of patients were 46.4 ± 13.0 years and 8.0 ± 7.0 years, respectively. Patients with SLE had higher VAT volume (p = 0.0015) and mass (p = 0.0017) than controls, especially in premenopausal and postmenopausal groups. The subanalysis of subjects with BMI less than 25 kg/m 2 indicated that patients had lower lean mass (p = 0.0005), fat-free mass (p = 0.0005), and fat-free mass index (p = 0.0001), but increased adiposity distribution than controls, including VAT volume and mass. However, overweight/obese patients had similar body composition with controls. The VAT volume correlated with BMI, age, menopausal status, hypertension, uric acid, creatinine, non-high-density lipoprotein cholesterol, and triglyceride in both groups. In the patient group, the VAT volume correlated with disease duration,

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Section: Introductionmentioning

confidence: 99%

Altered body composition and increased visceral adipose tissue in premenopausal and late postmenopausal patients with SLE

Shang

Zeng

et al. 2019

Clin Rheumatol

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“…The high prevalence of traditional cardiovascular risk factors together with the burden of the systemic inflammatory response sustains the increased cardiovascular risk in chronic inflammatory rheumatic diseases [1][2][3][4][5][6][7][8] . Although a systematic review found inconsistent results with respect to the increased vascular damage in PMR 13 , some studies do support this item 10,25 .…”

Section: Discussionmentioning

confidence: 99%

An exploratory cross-sectional study of subclinical vascular damage in patients with polymyalgia rheumatica

Silvestri

Ciciarello

Sessa

et al. 2020

Sci Rep

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the aim of the study was to investigate the presence of subclinical vascular damage in polymyalgia rheumatica (pMR). We enrolled pMR patients having major cardiovascular risk factors (McVRf) and, as controls, patients with McVRf. All underwent: color Doppler ultrasound to evaluate the common carotid intima-media thickness (iMt), the anterior-posterior abdominal aortic diameter (ApAD), and the prevalence of carotid artery stenosis; the cardio-ankle vascular index (cAVi) to measure arterial stiffness together with the ankle-brachial index (ABI) to investigate the presence of lower-extremity peripheral arterial disease. finally, we measured the serum levels of adipocytokines implicated in vascular dysfunction. As a result, 48 PMR and 56 MCVRF patients were included. An increase of IMT (1.

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“…Our data also support the use of non-invasive techniques such as applanation tonometry of the radial artery to assess the accelerated progression of atherosclerotic damage of the vessel wall in SLE patients. It is particularly important to stratify high-risk patients in order to plan an appropriate therapeutic approach for SLE patients and control traditional risk factors to avoid subclinical vascular impairment evolving into manifest cardiovascular events [48]. Therefore, early detection of increased aortic stiffness in these patients may be beneficial to highlight the vascular damage and to prompt an early therapeutic intervention.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory, Serological and Vascular Determinants of Cardiovascular Disease in Systemic Lupus Erythematosus Patients

Mercurio

Lobasso

Barbieri

et al. 2019

IJMS

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Background and aim: Systemic lupus erythematosus (SLE) is associated with increased risk of cardiovascular disease (CVD). Among many mechanisms, accelerated atherosclerosis, endothelial dysfunction, and hypercoagulability play a main role. Here, we investigate whether inflammatory, serological and clinical markers of SLE determine and correlate with arterial stiffness in SLE patients. Materials and methods: Routine blood samples, inflammatory mediators, specific antibodies, and 24 h proteinuria were measured in 43 SLE patients and 43 age and sex-matched controls using routine laboratory assays. We also assessed arterial stiffness by measuring radial artery applanation tonometry-derived augmentation index (AI), normalized AI (AIx@75), aortic pulse pressure, central systolic, diastolic and peripheral blood pressure. Results: SLE patients showed a significantly greater arterial stiffness vs. controls, as demonstrated by the significantly higher AIx@75 and aortic pulse pressure. Interestingly, regression analysis showed that age, systolic pulse pressure, inflammatory markers (erythrocyte sedimentation rate and C-reactive protein), daily dose of glucocorticoids, and cumulative organ damage positively correlated with arterial stiffness. Conclusions: SLE patients show increased arterial stiffness which correlates with markers of inflammation, that is involved in early alterations in arterial walls. Applanation tonometry can be used to screen SLE patients for subclinical vascular damage to implement prevention strategies for CVD.

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Cardiovascular risk factors, burden of disease and preventive strategies in patients with systemic lupus erythematosus: a literature review

Cited by 24 publications

References 95 publications

Altered body composition and increased visceral adipose tissue in premenopausal and late postmenopausal patients with SLE

Altered body composition and increased visceral adipose tissue in premenopausal and late postmenopausal patients with SLE

An exploratory cross-sectional study of subclinical vascular damage in patients with polymyalgia rheumatica

Inflammatory, Serological and Vascular Determinants of Cardiovascular Disease in Systemic Lupus Erythematosus Patients

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