1,24-Dihydroxyvitamin D<sub>3</sub>(tacalcitol) prevents skin T-cell infiltration

Yamanaka, Keiichi; Kakeda, Masato; Kitagawa, Harukazu; Tsuda, K.; Akeda, Tomoko; Kurokawa, Ichiro; Gabazza, Esteban C.; Kupper, Thomas S.; Mizutani, Hitoshi

doi:10.1111/j.1365-2133.2010.09692.x

Cited by 22 publications

(18 citation statements)

References 22 publications

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“…Vitamin D may act through its receptor to improve autoimmune skin conditions by inhibiting the expression of pro-inflammatory cytokines genes such as tumor necrosis factor alpha and interferon gamma [15]. Tacalcitol (1,24-dihydroxyvitamin D) has also been shown to downregulate cutaneous lymphocyte-associated antigen expression, preventing CD4+ T cell skin infiltration [16]. Studies have generally shown mild benefit in repigmentation by adding topical vitamin D analogues either in combination with topical steroid therapy, phototherapy, or 308-nm excimer laser therapy [17,18,19].…”

Section: Discussionmentioning

confidence: 99%

Comorbidities Associated with Vitiligo: A Ten-Year Retrospective Study

Sheth¹,

Guo²,

Qureshi³

2013

Dermatology

100

102

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Background: Vitiligo is a common disorder of depigmentation that has been associated with other autoimmune diseases. No recent large-scale data exist on the rates of comorbidities associated with vitiligo from the United States population. Objectives: To identify the prevalence of comorbidities as well as associated laboratory abnormalities in vitiligo patients. Methods: All medical records dating from January 1, 2000 to June 21, 2011 within the Research Patient Data Repository were evaluated retrospectively using a novel artificial intelligence-based computer program. A total of 3,280 patients carrying the diagnosis of vitiligo were identified using ICD-9 code 709.01. We randomly selected 300 patients and validated the diagnosis by manually reviewing their medical records. These results were used to create a model that was then applied to the larger set yielding 2,441 true vitiligo patients. 1,657 (68%) were diagnosed by dermatologists and 784 (32%) by non-dermatologists. We identified the prevalence of other comorbid autoimmune conditions by searching problem lists of vitiligo patients and collected laboratory data from the first available data point in the system for each patient. Results: Women were more frequently represented (57.6%) than men (42.4%). The majority of vitiligo patients were White/Caucasian (56.9%), followed by Hispanic/Latino (19.4%). 565 (23%) had one of the following comorbidities: 287 thyroid-related, 186 psoriasis, 72 rheumatoid arthritis, 59 alopecia areata, 55 inflammatory bowel disease, 53 systemic lupus and 20 type I diabetes mellitus. 41% had elevated anti-nuclear antibody levels. Almost half of the patients tested had elevated thyroid peroxidase antibodies. Over 50% of the patients tested had low or insufficient levels of 25-OH vitamin D. Conclusion: We found a high prevalence of comorbidities among individuals with vitiligo presenting to teaching hospitals in Boston, Mass. Comorbid autoimmune conditions were seen in 23% of vitiligo patients, thyroid disorders and psoriasis being the most common. Screening for these conditions, especially thyroid disorders, should be considered in vitiligo patients.

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Section: Discussionmentioning

confidence: 99%

Comorbidities Associated with Vitiligo: A Ten-Year Retrospective Study

Sheth¹,

Guo²,

Qureshi³

2013

Dermatology

100

102

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“…Vitamin D ligands suppress cytotoxic T lymphocytes [37] and inhibit several pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) [38,39] and interferon gamma [38] which are known to play an important role in T cell trafficking to the skin [40,41]. Furthermore active vitamin D is known to increase the levels of immunosuppressive cytokine IL-10 [42], and gene polymorphisms of the IL-19 cluster, which belongs to the IL-10 family, have been found to be associated with vitiligo [43].…”

Section: Discussionmentioning

confidence: 99%

Analysis of Vitamin D Receptor Gene Polymorphisms in Vitiligo

Aydıngöz

Bingül²,

Doğru‐Abbasoğlu³

et al. 2012

Dermatology

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Background: Vitiligo is a progressive depigmenting disorder characterized by the loss of functional melanocytes from the epidermis. The etiopathogenesis of vitiligo is still unclear. Vitamin D has both stimulatory and protective effects on melanocytes and acts through its nuclear vitamin D receptor (VDR) on target cells. Aim: The aim of this study was to investigate the association between VDR gene polymorphisms and susceptibility to vitiligo. Methods: 98 patients with vitiligo and 216 age- and sex-matched controls recruited from dermatology outpatients attending the same department were included in the study. Genomic DNA was extracted from peripheral blood leukocytes using a DNA isolation kit. The VDR polymorphisms of BsmI, ApaI, TaqI, FokI and Cdx2 were investigated by rapid capillary PCR with melting curve analysis. Differences in genotype distributions and allele frequencies in vitiligo cases versus controls were compared for statistical significance using χ² test. Results: Subjects with TaqI polymorphism had a 2.23-fold increased risk of developing vitiligo. Furthermore, a haplotype analysis showed that BsmI/ApaI/TaqI/FokI/Cdx2 GCCCG wassignificantly overrepresented in the vitiligo patients in comparison with controls (p = 0.031). Conclusion: This study showed that VDR TaqI gene polymorphism and the haplotype BsmI/ApaI/ TaqI/FokI/Cdx2 GCCCG may be considered as novel risk factors in vitiligo.

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“…Studies investigating the effect of vitamin D on homing of memory T cells to the skin are contradictory. While some studies suggested that 1,25(OH) 2 D 3 and its analogs prevent skin T-cell infiltration by downregulating the expression of CLA [41,42], other studies showed that 1,25(OH) 2 D 3 induces CCR10 receptor expression on T cells promoting their homing to cutaneous sites [43,44,45]. Recently, a study has shown that seasonal variation in vitamin D level affects the skin-homing receptor expression with increased levels of CLA during the summer [46].…”

Section: Role Of Vitamin D In Skin Physiologymentioning

confidence: 99%

Vitamin D and the Pathophysiology of Inflammatory Skin Diseases

Umar

Sastry

Ali

et al. 2018

Skin Pharmacol Physiol

134

135

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Background: Vitamin D is a secosteroid, which was initially known for its skeletal role; however, in recent years, its functions in different organs have been increasingly recognized. In this review, we will provide an overview of vitamin D functions in the skin physiology with specific focus on its role in certain inflammatory skin conditions such as psoriasis and atopic dermatitis. Methods: A comprehensive literature search was carried out in PubMed and Google Scholar databases using keywords like “vitamin D,” “skin,” “atopic dermatitis,” and “psoriasis.” Only articles published in English and related to the study topic were included in this review. Results: Vitamin D is integrally connected to the skin for its synthesis, metabolism, and activity. It regulates many physiological processes in the skin ranging from cellular proliferation, differentiation, and apoptosis to barrier maintenance and immune functions. Vitamin D deficiency is associated with the risk of psoriasis and atopic dermatitis, and several clinical/observational studies have suggested the beneficial effect of vitamin D in the therapy of these 2 inflammatory skin disorders. Conclusions: Vitamin D exerts a pleiotropic effect in the skin and could be an important therapeutic option for psoriasis and atopic dermatitis.

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1,24-Dihydroxyvitamin D₃(tacalcitol) prevents skin T-cell infiltration

Abstract: These findings suggest that tacalcitol reduces skin inflammation by partially downregulating CLA expression levels.

Cited by 22 publications

References 22 publications

Comorbidities Associated with Vitiligo: A Ten-Year Retrospective Study

Comorbidities Associated with Vitiligo: A Ten-Year Retrospective Study

Analysis of Vitamin D Receptor Gene Polymorphisms in Vitiligo

Vitamin D and the Pathophysiology of Inflammatory Skin Diseases

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1,24-Dihydroxyvitamin D3(tacalcitol) prevents skin T-cell infiltration

Abstract: These findings suggest that tacalcitol reduces skin inflammation by partially downregulating CLA expression levels.

Cited by 22 publications

References 22 publications

Comorbidities Associated with Vitiligo: A Ten-Year Retrospective Study

Comorbidities Associated with Vitiligo: A Ten-Year Retrospective Study

Analysis of Vitamin D Receptor Gene Polymorphisms in Vitiligo

Vitamin D and the Pathophysiology of Inflammatory Skin Diseases

Contact Info

Product

Resources

About

1,24-Dihydroxyvitamin D₃(tacalcitol) prevents skin T-cell infiltration