1-(2-hydroxy-3,4,5,6-tetramethoxyphenyl)-3-phenylpropene from Lindera lucida

Conformational, electronic and antioxidant properties of lucidone, linderone and methyllinderone: DFT, QTAIM and NBO studies

“…The separation in the IP values for the different structures is also smaller in solution than in vacuo, indicating that, in solution, most compounds have nearly similar tendency to react through ET mechanism. The ET mechanism may offer an explanation for the observation that LD, LR and mLR have the ability to scavenge free radical species, as reported by some experimental researchers [2][3][4][5][6][7][8][9][10]. In all the media, the tendency to scavenge free radicals increases with the increase in the number of OCH 3 groups as substituents on the main moiety, in this way, mLR and LD have the highest and the lowest tendency, respectively, to scavenge free radical species.…”

“…Lucidone (LD), linderone (LR) and methyllinderone (mLR) are acylcyclopentene-1,3-dione derivatives isolated from Lindera erythrocarpa Makino plant, which belongs to the large Lauraceae family and consists mostly of trees or shrubs [1][2][3][4][5][6]. In most part of the world where this plant is found, it is utilised as a traditional medicine for the treatment of several illnesses including analgesic, digestive, diuretic and headache problems [1].…”

“…In most part of the world where this plant is found, it is utilised as a traditional medicine for the treatment of several illnesses including analgesic, digestive, diuretic and headache problems [1]. The isolated compounds exhibit several biological activities including antitumor, antiviral, antioxidant, antibacterial, antifungal and antiinflammatory activities, [1][2][3][4][5][6][7][8][9][10][11][12][13]. Therefore, LD, LR and mLR are attractive for utilisation in the therapeutical treatment of degenerative diseases because they are isolated from natural sources and therefore have potential to reduce the risk of drug toxicity [11,12].…”