1,2:5,6-Di-O-Cyclohexylidene-d-Mannitol and Its Bis(Trimethylsilyl) Ether in the Dithiophosphorylation Reactions

Abstract

ABSTRACT:The reaction of 2,4-diaryl 1,3,2,4-dithiadiphosphetane-2,4-

Cinchona Alkaloids in the Synthesis of Chiral Salts of Phosphorus Dithioacids on the Basis of 1,2:3,4‐Di‐O‐isopropylidene‐α‐D‐galactopyranose

“…One or two hydroxyl group respectively remained unprotected. These free hydroxyl group can react with phosphorus sulfides ,. α‐D‐Glucofuranose and α‐D‐allofuranose diacetonides react with 2,4‐diorganyl 1,3,2,4‐dithiadiphosphetane‐2,4‐disulfides to form optically active dithiophosphonic acids transformed into the corresponding ammonium salts by the treatment of n ‐hexadecylamine .…”

“…Protection of some hydroxyl groups of monosaccharides is required . We have earlier used diacetonide protection of four hydroxyl groups of α‐D‐glucofuranose and α‐D‐allofuranoseas well as D‐mannitol to obtain phosphorus dithioacids ,. One or two hydroxyl group respectively remained unprotected.…”

“…α‐D‐Glucofuranose and α‐D‐allofuranose diacetonides react with 2,4‐diorganyl 1,3,2,4‐dithiadiphosphetane‐2,4‐disulfides to form optically active dithiophosphonic acids transformed into the corresponding ammonium salts by the treatment of n ‐hexadecylamine . The reaction of 2,4‐diaryl 1,3,2,4‐dithiadiphosphetane‐2,4‐disulfide with 1,2:5,6‐di‐ O ‐cyclohexylidene‐D‐mannitol results in optically active bisaryldithiophosphonic acids transformed into the bis( n ‐hexadecyldiammonium) salts . Furanoside backbone was chainged into α‐D‐galactopyranose species and its diacetonide 1 was reacted with tetraphosphorus decasulfide 2 in 8:1 molar ratio in the benzene suspension at 50 °C for 2 h to form dithiophosphoric acid 3 (Scheme ).…”

Modified D-Glucofuranose Computationally Screening for Inhibitor of Breast Cancer and Triple Breast Cancer: Chemical Descriptor, Molecular Docking, Molecular Dynamics and Qsar

“…But with the help of the newly developed computational chemistry method, it has been possible to design an effective drug, and check all the pharmacokinetic parameters of the drug in a concise time, such as pass prediction, docking, molecular dynamics, and ADMET easily (24). On the other hand, the D-glucofuranose and its derivative have already been identified as a potential compound by many renowned researchers (25) for the treatment as an antifungal (25) antibacterial, antiviral (26)(27)(28)(29), and anticancer activity (30). Since D-glucofuranose and its derivatives have already been found to have potential as antimicrobial and anticancer before (27,29,31,32), this is why derivatives of this compound have been taken and performed different types of computational studies.…”

“…On the other hand, the D-glucofuranose and its derivative have already been identified as a potential compound by many renowned researchers (25) for the treatment as an antifungal (25) antibacterial, antiviral (26)(27)(28)(29), and anticancer activity (30). Since D-glucofuranose and its derivatives have already been found to have potential as antimicrobial and anticancer before (27,29,31,32), this is why derivatives of this compound have been taken and performed different types of computational studies. Firstly, molecular docking investigation was conducted, and the docking score has been reported higher compared to the standard range.…”