1,2,4-Thiadiazolidin-3,5-diones as novel hydrogen sulfide donors

Role of hydrogen sulfide in endothelial dysfunction: Pathophysiology and therapeutic approaches

“…Numerous in vitro , ex vivo and in vivo studies demonstrated the vasoactive role of H 2 S, confirming the hypothesis that H 2 S importantly contributes to the regulation of vascular tone [22] , [23] . In fact, like NO, H 2 S assures the maintenance of vascular homeostasis by the regulation of the complex balance of several components, including vasodilation responses as widely demonstrated for molecules able to release H 2 S [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] .…”

Structure-activity relationships study of isothiocyanates for H2S releasing properties: 3-Pyridyl-isothiocyanate as a new promising cardioprotective agent

“…Due to the intriguing biological activities of H 2 S in the cardiovascular function, compounds able to generate exogenous H 2 S, are viewed as promising cardioprotective agents. In this scenario, different classes of H 2 S-donors have been described in the literature, such as GYY4137 [12] , thiadiazolidin-3,5-diones [13] , arylthioamides [14] , iminothioethers [15] , mercaptopyruvate [16] , dithioates [17] . Furthermore, also natural [18] , [19] and synthetic [20] isothiocyanates are known to generate H 2 S with a slow kinetic and in an l -Cysteine dependent manner.…”

An Innovative Hydrogen Peroxide‐Sensing Scaffold and Insight Towards its Potential as an ROS‐Activated Persulfide Donor

“…Given the clear limitations of inorganic salts in biological studies, several small molecule donor compounds have since been developed that were chemically engineered to release H 2 S, and other reactive sulfur species, via hydrolysis [18] or in response to a specific biological trigger, such as cellular thiols or enzymes [19–31] . Indeed, many of these donors were shown to more closely mimic the natural production of RSS, producing more favorable physiological responses [32–35] …”

“…Given the clear limitations of inorganic salts in biological studies,s everal small molecule donor compounds have since been developed that were chemically engineered to release H 2 S, and other reactive sulfur species,v ia hydrolysis [18] or in response to aspecific biological trigger,such as cellular thiols or enzymes. [19][20][21][22][23][24][25][26][27][28][29][30][31] Indeed, many of these donors were shown to more closely mimic the natural production of RSS,producing more favorable physiological responses. [32][33][34][35] Of particular interest to us,h owever,w ere the reported donors of Pluth, Matson, and Chakrapani which were shown to selectively release H 2 Sprecursors,including persulfides,in response to reactive oxygen species (ROS).…”