1,2,3‐Triazole hybrids with anti‐HIV‐1 activity

Abstract

The human immunodeficiency virus type 1 (HIV‐1) is the major etiological agent responsible for the acquired immunodeficiency syndrome (AIDS), which is a serious infectious disease and remains one of the most prevalent problems at present. Currently, combined antiretroviral therapy is the primary modality for the treatment and management of HIV/AIDS, but the long‐term use can result in major drawbacks such as the development of multidrug‐resistant viruses and multiple side effects. 1,2,3‐Triazole is the common framework in the development of new drugs, and its derivatives have the potential to inhibit various HIV‐1 enzymes such as reverse transcriptase, integrase, and protease, consequently possessing a potential anti‐HIV‐1 activity. This review covers the recent advances regarding the 1,2,3‐triazole hybrids with potential anti‐HIV‐1 activity; it focuses on the chemical structures, structure–activity relationship, and mechanisms of action, covering articles published from 2010 to 2020.

1,2,3-Triazole-Containing Compounds as Anti–Lung Cancer Agents: Current Developments, Mechanisms of Action, and Structure–Activity Relationship

“…Moreover, 1,2,3-triazole could form diverse non-covalent interactions, such as hydrogen bonds, van der Waals forces, and dipole-dipole bonds with various enzymes, proteins, and receptors (Bonandi et al, 2017;Bozorov et al, 2019). Hence, 1,2,3-triazole derivatives exhibit a variety of promising biological properties, including antibacterial (Zhang, 2019;Xu, 2020), antimalarial (Chu et al, 2019;Feng et al, 2020), antitubercular (Zhang et al, 2017;Yan et al, 2020), antiviral (Rani et al, 2020;Feng et al, 2021), and anticancer (Lal and Yadav, 2018;Slavova et al, 2020) activities. For example, 1,2,3-triazoles could exert the anticancer potential by inducing the cell cycle arrest and apoptosis of cancer cells.…”

Design and Synthesis of New 5-aryl-4-Arylethynyl-1H-1,2,3-triazoles with Valuable Photophysical and Biological Properties

“…The biological properties of triazole derivatives are very diverse. Currently, among the most widely studied types of activity are: antibacterial [ 14 , 15 ], antiviral [ 16 ], and anticancer [ 17 , 18 ].…”

Design, Synthesis and Molecular Docking of Novel Acetophenone-1,2,3-Triazoles Containing Compounds as Potent Enoyl-Acyl Carrier Protein Reductase (InhA) Inhibitors

“…Due to their well-documented therapeutic potential, 1,2,3-triazole analogues are attractive target substances for researchers worldwide. They are important antiviral [2,3], antibacterial [4][5][6][7], antifungal [8,9], antimalarial [10,11], anticancer [12][13][14][15][16][17][18], analgesic [11], antihypertensive [12], anticonvulsant [19], and CNS depressing [20] agents. Furthermore, as enticing linker units suitable for connecting two pharmacophores in order to develop novel polyfunctional drugs, 1,2,3-triazoles have become increasingly relevant and important in the generation of bioactive and multifunctional drugs [21].…”