1,1,2-Tribromoethyl arenes: novel and highly efficient precursors for the synthesis of 1-bromoalkynes and α-bromoketones

Abstract

In this work, we develop a novel method to synthesize 1,1,2-tribromoethyl arenes, which can be easily transformed to 1-bromoalkynes via base-mediated elimination reaction. The bromination reagent was in situ generated...

Bromide Oxidation: A Safe Strategy for Electrophilic Brominations

“…The acidic form, bromic acid, is unstable and will revert back to bromine when enough bromide is present to allow Equation (12) to proceed [13,71] . This can then be used to brominate organics, either in an electrophilic reaction, [71–72] or, when adding a radical initiator such as AIBN or through irradiation, in a radical reaction [71,73] …”

Palladium-Catalyzed Sequential Three-Component Cross-Coupling to 1,3-Dienes: Employing Alkenes as Hydride and Alkenyl Donors

“…46−7.45 (m, 1H), 7.36− 7.33 (m, 2H), 7.28−7.24 (m, 1H); 13 C{ 1 H} NMR (100 MHz, CDCl 3 ) δ 134.2,131.8,130.1,129.5,129.0,124.3,78.7,benzene (2n). 27 White solid (79%, 2.04 g); isolated by column chromatography (petroleum ether); 1 H NMR (400 MHz, CDCl 3 ) δ 7.57 (t, J = 1.8 Hz, 1H), 7.45 (ddd, J = 8.1, 2.0, 1.1 Hz, 1H), 7.35 (dt, J = 7.8, 1.2 Hz, 1H), 7.15 (t, J = 8.0 Hz, 1H); 13 C{ 1 H} NMR (100 MHz, CDCl 3 ) δ 134 .7, 131.8, 130.5, 129.7, 124.5, 122.1, 78.5, 51.7.…”