A novel and efficient palladium-catalyzed annulation of anilines with bromoalkynes for the synthesis of 2-phenylindoles has been described. This approach features excellent regio-and stereoselectivities and good functional group tolerance. Preliminary mechanistic studies indicate that anilines undergo anti-nucleophilic addition to bromoalkynes to generate (Z)-N-(2-bromo-1-phenylvinyl) anilines, followed by sequential C−H functionalization to deliver different substituted 2-phenylindoles. This method provides potential applications for the construction of various biologically active compounds.
This report discloses a novel Pd-catalyzed sequential
three-component
multiple reaction of alkenes, bromoalkynes, and boronic acids using
alkenes as hydride and alkenyl donors, leading to highly stereoselective
assembly of (Z,E)-1,3-diene derivatives.
Mechanistic studies demonstrate that the generation and reutilization
of palladium hydride species are critical to the success of this transformation.
In addition, the good functional group compatibility, late-stage modification,
and investigation of photophysical properties of 1,3-diene products
illustrate the synthetic value of this strategy.
This paper consider the finite-time boundary stabilization for a first-order hyperbolic system with integral kernel and lower order term. Via choosing a suitable integral transformation converting the original system into a finite-time stable object system, then, we obtain the control law and certify the finite-time stabilization of the closed-loop system combined with the finite-time stability of object system and invertibility of forward transformation.
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