069 Predictors of Contrast Induced Acute Kidney Injury Following Percutaneous Coronary Angiogram - Single Centre Experiences

Abstract

respiratory, cutaneous/ limb and urinary tract (41.7%, 26.4% and 20.8% respectively). Positivity of blood cultures were 43.1%. A total of 66 subjects (91.7%) were mechanically ventilated (median duration 5 days), while 59 (81.9%) required inotropic support (median duration 3 days). Modalities for RRT were haemodialysis (HD) in 84.7% of cohort (n ¼ 61), peritoneal dialysis (PD) in 4.2% of cohort (n ¼ 3), or a combined modality of HD and PD in 11.1% of cohort (n ¼ 8). Median HD catheter days and PD catheter days were 4 days (IQR 3 days) and 2 days (IQR 3 days) respectively. Percentages of subjects receiving 1, 2, 3 and > 4 sessions of HD were 44.1%, 26.5%, 8.8% and 20.6% respectively. Median length of hospitalisation was 14 days (IQR 16 days) with in-hospital mortality of 54.2% (n¼ 39). Causes of death attributed directly to index infection, nosocomial infection and noninfectious causes were 74.4%, 10.3% and 15.4% respectively. Among survivors, 11 (34.4%) were functionally dependent at discharge. Predictors of mortality were use of mechanical ventilation, inotrope use, younger patients, and cutaneous/ limb infection. Comorbidities, CKD status, CCI, positivity of blood culture and SOFA score did not predict mortality. Conclusion: Mortality and morbidity remain high for patients with SA-AKI requiring RRT, primarily driven by the index infection.

Evaluation of Remdesivir Utilization Pattern in Critically Ill Patients With COVID-19 in Jazan Province

“…SARS-CoV-2 infection predominately involves the host's respiratory system; however, SARS-CoV-2-induced renal and hepatic damage has also been reported [31,32]. Major pathophysiological features of liver injury in SARS-CoV-2 infection include hepatic lobular and portal inflammation, steatosis, congestion, focal necrosis with neutrophil infiltration, microthrombosis, and mild-to-moderate increases in liver aminotransferase (five times the upper limit of normal {ULN}) [33].…”