065 the Osteoarthritis-Associated Gene Gdf5 Is Under Epigenetic Regulation in Patient Tissues and in a Range of Human Cell Lines

Reynard, Louise N.; Gravani, Athanasia; Loughlin, John

doi:10.1016/s1063-4584(10)60092-1

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2011

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“…At the 2010 OARSI congress we heard that GDF5 is under epigenetic regulation in cell-lines and in patient tissues and that this regulation may be influenced by rs143383 and a second 5 0 UTR SNP, rs143384, with both of these SNPs forming CpG sites when present in their C-allele forms 13 . Through a deep sequencing analysis of over 1900 OA cases and controls it was also reported that in Europeans GDF5 lacks rare variants 14 .…”

Section: Gdf5mentioning

confidence: 99%

Osteoarthritis year 2010 in review: genetics

Loughlin

2011

Osteoarthritis and Cartilage

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At the 2010 Osteoarthritis Research Society International (OARSI) congress in Brussels I was asked to present on "Genetics" in the "Year in Review" session. This gave me an opportunity to reflect on the talk that I gave on the same topic at the 2007 OARSI congress in Ft Lauderdale, Florida. My 2007 talk was very upbeat and ended with the hostage to fortune statement "The next few years will provide tremendous clarity in our genetic understanding of osteoarthritis".

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Section: Gdf5mentioning

confidence: 99%