Osteoarthritis year 2010 in review: genetics

Loughlin, John

doi:10.1016/j.joca.2011.01.020

Cited by 23 publications

(14 citation statements)

References 23 publications

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“…Most genes identified have not been consistently replicated in later studies or in cohorts from different geographical regions. An exception is growth/differentiation factor 5 (GDF‐5), a protein involved in joint formation from the bone morphogenic protein family [24]. GDF‐5 has shown consistent associations with knee OA in both East Asian and white European cohorts, reaching genome‐wide significance in the latter; less consistent associations have been seen with hip OA [25].…”

Section: Risk Factors For Oamentioning

confidence: 99%

Epidemiology of Osteoarthritis and Associated Comorbidities

Suri

Morgenroth

Hunter

2012

PM&R

204

145

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Osteoarthritis (OA) is the most common cause of walking-related disability among older adults in the United States, and the prevalence and incidence of OA are increasing rapidly. Systemic and local risk factors for knee OA have been identified, and obesity and joint injury appear to be the strongest risk factors that are both modifiable and have the potential for substantial impact on a population level. The risk factors for functional decline and disability in persons with symptomatic OA have been examined in relatively few studies. The course of functional decline in persons with symptomatic OA on a population level is generally one of stable to slowly deteriorating function, but on an individual level, many patients maintain function or improve during the first 3 years of follow-up. Obesity stands out as one of few modifiable risk factors of OA that also is a potentially modifiable predictor of functional decline. Physical activity also appears to have a substantial protective impact on future OA-related disability. Further epidemiologic studies and randomized controlled trials are needed to prioritize prevention through targeting these modifiable risk factors for OA and related disability.

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Section: Risk Factors For Oamentioning

confidence: 99%

Epidemiology of Osteoarthritis and Associated Comorbidities

Suri

Morgenroth

Hunter

2012

PM&R

204

145

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“…Investigation of the genetic component of osteoarthritis (OA) susceptibility has yielded the identification of several loci achieving genome-wide significance or consistent replication [1-3]. These loci are insufficient to account for the heritability of OA, which has been estimated as 49 to 78% for knee OA in twin and family studies [4-6].…”

Section: Introductionmentioning

confidence: 99%

“…Multiple possible causes of this discrepancy, which has become known as the missing heritability problem of complex diseases, have been discussed [7]. Some have a particular importance in OA, like the difficulties in discriminating between cases and controls, the variability in phenotype definitions and the relatively small size of genome wide association studies (GWAS) in which OA has been studied in comparison with other diseases [3,8]. Other causes are shared by most complex diseases.…”

Section: Introductionmentioning

confidence: 99%

Association of a BMP5 microsatellite with knee osteoarthritis: case-control study

et al. 2012

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IntroductionWe aimed to explore the involvement of a multiallelic functional polymorphism in knee osteoarthritis (OA) susceptibility as a prototype of possible genetic factors escaping GWAS detection.MethodsOA patients and controls from three European populations (Greece, Spain and the UK) adding up to 1003 patients (716 women, 287 men) that had undergone total knee joint replacement (TKR) due to severe primary OA and 1543 controls (758 women, 785 men) lacking clinical signs or symptoms of OA were genotyped for the D6S1276 microsatellite in intron 1 of BMP5. Genotype and mutiallelic trend tests were used to compare cases and controls.ResultsSignificant association was found between the microsatellite and knee OA in women (P from 3.1 x10-4 to 4.1 x10-4 depending on the test), but not in men. Three of the alleles showed significant differences between patients and controls, one of them of increased risk and two of protection. The gender association and the allele direction of change were very concordant with those previously reported for hip OA.ConclusionsWe have found association of knee OA in women with the D6S1276 functional microsatellite that modifies in cis the expression of BMP5 making this a sounder OA genetic factor and extending its involvement to other joints. This result also shows the interest of analysing other multiallelic polymorphisms.

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“…So sind unterschiedliche Signalkaskaden der Skelettentwicklung, der extrazellulären Matrixproteine, der Chondrozytenphänotypen, der Apoptose als auch inflammatorischer Moleküle, wie des Zytokin-, Prostaglandin, Arachidonsäure-Stoffwechsels als auch der Proteaseninteraktion beschrieben worden [46,47]. Genetische Faktoren sind ebenso in die Entwicklung einer Arthrose (Osteoarthritis; OA) involviert [28], wie Vitamin-D-Mangel und Adipositas als einflussgebende Prädiktoren beschrieben wurden [6]. Insgesamt wird von einer Interaktion sowohl angeborener, erworbener als auch Umweltfaktoren ausgegangen [6].…”

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Entzündliche Fingergelenkspolyarthrose – Herausforderungen in der Diagnostik und Therapie

Klaus

Detert

2014

Dtsch med Wochenschr

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Symptomatic osteoarthritis of the hand occurs in 5-20 % of the population ≥ 40 years. The diagnosis is made based on the clinical appearance, e. g. bony enlargements of small finger joints, pain and short morning stiffness. Laboratory or X-ray examinates can however be useful to exclude other rheumatic diseases. Non-pharmacological therapy options include patient education, physio- and occupational therapeutic exercise to strengthen the muscles and mobilisation. Topical non-steroidal anti-inflammatory drugs (NSAID) or capsaicin can be effective for mild to intermediate pain. Systemic therapeutics are paracetamol, NSAID or coxibs. Innovative therapy options are currently under investigation in clinical trials.

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Osteoarthritis year 2010 in review: genetics

Cited by 23 publications

References 23 publications

Epidemiology of Osteoarthritis and Associated Comorbidities

Epidemiology of Osteoarthritis and Associated Comorbidities

Association of a BMP5 microsatellite with knee osteoarthritis: case-control study

Entzündliche Fingergelenkspolyarthrose – Herausforderungen in der Diagnostik und Therapie

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