055 Elevated blood pressure in offspring born to hypertensive pregnancy: is endothelial dysfunction the underlying vascular mechanism?

Preeclampsia, prematurity and cardiovascular health in adult life

“…Studies investigating arterial stiffness have been less conclusive; several have shown increased stiffness in preterm born individuals [9][10][11][12], while others have shown no difference [13,14]. We have shown in a large-scale follow-up study of preterm-born young adults, using cardiovascular magnetic resonance, that preterm birth per se does not relate to an increase in arterial stiffness [15,16].…”

“…This could explain why studies vary in their results depending on the frequency of these interventions within cohorts. Consistent changes in smaller conduit vessel size are less well described, but endothelial responses in later life have not been found to vary in relation to prematurity, unless other complications, such as preeclampsia, are also present [9,14,[17][18][19][20][21][22].…”

“…Specifically, as young adults, they exhibit endothelial dysfunction and increased carotid intima media thickness, a subclinical marker of atherosclerosis [9]. In addition, they have reductions in cardiac function that cannot be accounted for by prematurity alone, without additional cardiac structural changes [4].…”

Markers of Insulin Sensitivity in 12-Year-Old Children Born from Preeclamptic Pregnancies

“…[12][13][14][15][16][17][18][19] Other studies have reported on glucose metabolism in the offspring of mothers with preeclampsia. [20][21][22] The aim of the present study was to determine, using the Quantitative Insulin Sensitivity Check Index (QUICKI), whether preeclampsia influences insulin sensitivity (IS) in the offspring of affected mothers. In addition, insulin-like growth factor (IGF)-1 associated with transient physiological insulin resistance of puberty, 23 and IGF-binding protein-1 (IGFBP-1) and sex hormone-binding globulin (SHBG), 2 commonly used markers of IS, 24 14 Preeclampsia was defined as the development of hypertension and proteinuria (>300 mg of urinary protein in 24 hours) after 20 weeks of gestation.…”

“…These results are in accordance with our findings, although Miettola et al 21 did not report IS indices. In addition, Lazdam et al 22 found no significant differences in glucose or insulin levels in 24-year-old offspring born preterm from hypertensive or normotensive pregnancies.…”