“…Moreover, the properties of mucoadhesives allow for the crossing of biological barriers in pulmonary systemic absorption (Ajdary et al, 2018). In vivo, microparticles loaded with bronchodilators have low efficiency than conventional methods (Lai et al, 1993). However, corticosteroids-loaded polymeric NPs used to treat asthma, and chronic obstructive pulmonary illness exhibited deep penetration in the lung by aerosol administering (Singh et al, 2019).…”