0.1% Nepafenac reduces pain and increases patient comfort during cataract surgery

Oğurel, Tevfik; Onaran, Zafer; Örnek, Kemal

doi:10.1016/j.clae.2018.05.003

Cited by 4 publications

(5 citation statements)

References 23 publications

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“…This finding has been previously reported both in cataract (Hovanesian et al, 2015) and vitreoretinal surgery (Porela-Tiihonen et al, 2013b). Conversely, Ogurel et al did not find statistically significant difference in mean VAS pain score when first and second eyes were compared (Oğurel et al, 2018).…”

Section: Discussionsupporting

confidence: 73%

“…The VAS Pain results showed that the range of pain during surgery was 2.13 ± 0.36 (SD) in the group with cryoanalgesia and 2.6 ± 0.37 (SD) in reference group. Moreover, in a study evaluating analgesic effectiveness of 0.1% nepafenac during cataract surgery, the pain intensity was higher than our scores (Oğurel et al, 2018). Mean VAS Pain score (± SD) was 2.15 (± 1.23) in the treatment group and 4.15 (± 1.13) in the placebo group (p = 0.024).…”

Section: Discussioncontrasting

confidence: 65%

“…Numaga et al found that 0.1% nepafenac seems to be a safe and efficacious ophthalmic suspension for postoperative inflammation and eye pain following cataract surgery or other ophthalmic procedures (Numaga et al, 2012). On the other hand, Ogurel et al evaluated analgesic effectiveness and patient satisfaction of 0.1% nepafenac in patients who underwent bilateral cataract surgery with VAS and VPS (Oğurel et al, 2018). They found that 0.1% nepafenac seems to reduce pain in case of routine clear corneal phacoemulsification with topical anesthesia and increase intraoperative patient comfort if used preoperatively.…”

Section: Discussionmentioning

confidence: 99%

“…To date, some studies have compared different types of cataract surgery anesthesia (Martin et al, 1998;Crandall et al, 1999;Oğurel et al, 2018). However, these trials investigated only off-label formulations (Crandall et al, 1999), compared various types of topical anesthesia (Crandall et al, 1999), used a single psychometric tool for pain measurement (Porela-Tiihonen et al, 2013b), considered additional postoperative analgesia (Donnenfeld et al, 2017), or had only a small sample size (Coelho et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Pain Following the Use of Anesthesia Formulation Among Individuals Undergoing Cataract Surgery: A Randomized Controlled Trial

et al. 2020

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To assess the pain intensity of two intracameral anesthetic solutions in patients undergoing cataract surgery and evaluate the factors influencing the patients' postoperative activities. Methods: Sixty-two patients undergoing cataract surgery were randomized to receive the study druga manufactured solution of 0.02% tropicamide/0.31% phenylephrine/1% lidocaine (Mydrane) or a traditional anesthetic formulation-solution of 1% lidocaine/ 0.025% adrenaline as an intraocular anesthetic. The pain intensity was assessed by Visual Analog Scale for Pain (VAS Pain) and Brief Pain Inventory-short form (BPI) on the next day after the surgery. Results: The mean pain score measured preoperatively with VAS Pain was 0.34 in Mydrane group and 0.09 in the reference group (p = 0.51). There were no statistically significant differences between the two anesthetic methods with respect to pain intensity during the surgery (p = 0.94) and the influence of pain during the last 24 h on activity (p = 0.79), mood (p = 0.31), social contacts (p = 0.29), sleep (p = 0.5) and the joy of life (p = 0.39). Additionally, there was no statistically significant influence of age, sex, lateralization, co-existing ophthalmological diseases (p = 0.98) and post-operative complications (p = 0.4) on the experienced pain measured during the surgery and in the last 24 h. Conclusions: New commercially available intraocular anesthetic solution (Mydrane™) seems to be as effective as off-label traditional anesthetic formulation, in reducing the pain experienced during cataract surgery under topical anesthesia.

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Section: Discussionsupporting

confidence: 73%

Section: Discussioncontrasting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pain Following the Use of Anesthesia Formulation Among Individuals Undergoing Cataract Surgery: A Randomized Controlled Trial

et al. 2020

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“…With the improvement of ICL surgical equipment and techniques, patients who undergo the surgery are increasingly concerned about their experience and satisfaction. ICL surgery generally uses topical anesthesia, which is fast, efficient, inexpensive, and can reduce the risk of nerve damage and respiratory depression [15][16][17][18]. Although superficial anesthetics are becoming increasingly varied and analgesic, achieving a pain-free intraoperative experience remains difficult.…”

Section: Discussionmentioning

confidence: 99%

Comparison of pain between bilateral ICL surgeries in patients with myopia

Xiao,

Liu

2024

BMC Ophthalmol

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Purpose The purpose of this study was to compare the preoperative anxiety, aqueous humor monocyte chemoattractant protein-1 (MCP-1) concentration, intraoperative pain, and degree of cooperation of the first eye implantable collamer lens (ICL) surgery with the second eye surgery, of the 1-day interval group with the 1-week interval group, and to investigate the possible causes of these differences, as well as to determine the appropriate interval between bilateral eye ICL surgeries. Method The study was a prospective observational study. A total of 120 patients who underwent bilateral ICL surgery at the Department of Ophthalmology, West China Fourth Hospital, Sichuan University, from July to September 2023, were enrolled. The patients were divided into a 1-day interval group and a 1-week interval group. The ICL surgery was performed on both eyes according to the schedule. Anxiety levels, aqueous humor MCP1, cooperativeness, surgical time, pain and satisfaction, and patients’ estimations of the time spent in the operation were recorded for each eye. The patients were instructed to recall the intraoperative pain of the first eye surgery after the operation of the second eye. Statistical analyses (two independent samples t-test,two paired samples t-test, the rank-sum test, the chi-square test, non-parametric test with multiple independent samples) were performed to compare the differences between each score in both eyes and two groups. Furthermore, we examined the relationship between pain levels and the reproductive history of the patients. Results In the 1-day interval group, male/female is 22/52, average age is 25.24±5.00. In the 1-week interval group, male/female is 17/29, average age is 25.39±5.57. There was no statistically significant difference between the two groups. In both groups, patients were less nervous, had significantly more pain, had less surgical satisfaction, had a longer estimated operative time, and had elevated preoperative MCP1 during the second eye operation. In the second eye surgery, the patient’s cooperation worsened, but it did not lead to an increase in surgical time. A significant proportion of patients, particularly in the 1-week interval group, recalled experiencing reduced pain during the first eye surgery. The 1-week interval group had a higher difference in all indicators between the bilateral surgeries. In the second eye surgery, patients in the 1-week interval group experienced more severe pain, less cooperation, longer estimated operation duration, and a greater MCP1 than those in the 1-day interval group. Conclusion Patients undergoing second eye ICL surgery had decreased nervousness, increased pain, decreased cooperation, and satisfaction, and increased MCP1 compared to the first eye surgery. It is recommended that an interval of about one week should be avoided between bilateral surgeries when developing a surgical schedule to improve patients’ cooperation, satisfaction, and comfort.

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The Effect of Preoperative Fear and Related Factors on Patients’ Postcataract Surgery Comfort Level: A Regression Study

Taylan

Çelik

2022

Journal of PeriAnesthesia Nursing

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0.1% Nepafenac reduces pain and increases patient comfort during cataract surgery

Cited by 4 publications

References 23 publications

Pain Following the Use of Anesthesia Formulation Among Individuals Undergoing Cataract Surgery: A Randomized Controlled Trial

Pain Following the Use of Anesthesia Formulation Among Individuals Undergoing Cataract Surgery: A Randomized Controlled Trial

Comparison of pain between bilateral ICL surgeries in patients with myopia

The Effect of Preoperative Fear and Related Factors on Patients’ Postcataract Surgery Comfort Level: A Regression Study

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