2007
DOI: 10.1152/japplphysiol.00397.2007
|View full text |Cite
|
Sign up to set email alerts
|

β-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters

Abstract: Carnosine (beta-alanyl-l-histidine) is present in high concentrations in human skeletal muscle. The ingestion of beta-alanine, the rate-limiting precursor of carnosine, has been shown to elevate the muscle carnosine content. We aimed to investigate, using proton magnetic resonance spectroscopy (proton MRS), whether oral supplementation with beta-alanine during 4 wk would elevate the calf muscle carnosine content and affect exercise performance in 400-m sprint-trained competitive athletes. Fifteen male athletes… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

25
307
6
8

Year Published

2008
2008
2019
2019

Publication Types

Select...
6
3

Relationship

1
8

Authors

Journals

citations
Cited by 260 publications
(346 citation statements)
references
References 46 publications
(61 reference statements)
25
307
6
8
Order By: Relevance
“…As such, we cannot con rm in the present study that muscle carnosine contents were signi cantly increased and, if so, what the magnitude of this increase was. However, supplementation with β-alanine at this level has consistently been shown to increase muscle carnosine concentrations by over 60% 8,11 , with others reporting no non-responders to β-alanine supplementation 11,21,31 . Indeed, only one participant from the series of muscle studies to-date has failed to respond to β-alanine supplementation with an increase in muscle carnosine 8 .…”
Section: Discussionmentioning
confidence: 99%
“…As such, we cannot con rm in the present study that muscle carnosine contents were signi cantly increased and, if so, what the magnitude of this increase was. However, supplementation with β-alanine at this level has consistently been shown to increase muscle carnosine concentrations by over 60% 8,11 , with others reporting no non-responders to β-alanine supplementation 11,21,31 . Indeed, only one participant from the series of muscle studies to-date has failed to respond to β-alanine supplementation with an increase in muscle carnosine 8 .…”
Section: Discussionmentioning
confidence: 99%
“…Data are compiled from subjects of previous studies from our laboratory. Carnosine concentration is measured by means of proton MRS, as previously described [1], and expressed relative to the water signal. …”
mentioning
confidence: 99%
“…Since increased carnosine storage results in reduced muscle pain and fatigue after physical exercise [36][37][38][39], many athletes are using beta-alanine as a food supplement. The therapeutic effects of increased carnosine storage have been barely explored in diseases such as diabetes, which are characterized by oxidative injury.…”
Section: Discussion and Future Perspectivesmentioning
confidence: 99%
“…Enzyme measurements for CNDP1 in human sera of healthy adults and diabetic patients have provided indications for post-translational modifications of CNDP1, which influence its prolonged enzyme activity by additional glycosylation [46]. In diabetic patients with microvascular complications, non-invasive measurement of tissue carnosine concentrations by proton magnetic resonance spectroscopy (1H-MRS) shows a significant reduction of carnosine concentrations in skeletal muscles of patients with type 2 diabetes, but not in patients with type 1 diabetes [36]. Oral administration of β-alanine, the rate limiting amino acid for the biosynthesis of carnosine [48], to healthy volunteers during 4 weeks resulted in reduced fatigue after physical exercise and in 30-50% increase of carnosine storage in peripheral muscle tissue, as determined again by proton-MRS [52].…”
Section: Discussion and Future Perspectivesmentioning
confidence: 99%