Herbal plant extracts are good resources to find functional compounds for cosmetic ingredient. In this study, the extract of Areca semen (A. semen) was studied for melanogenesis inhibition and antioxidant activity. The results showed that ethyl acetate fraction of A. semen contained phenolic contents, 301.35 ± 0.88 µg/mg, and exhibited potent antioxidant activity with IC 50 value of 1.02 ± 0.07 µg/mL. Further, FRAP value exhibited potent antioxidant activity with 9.07 ± 0.36 mM. Disk diffusion assay was performed for antibacterial activity. Ethyl acetate fraction of A. semen showed antibacterial activity against Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis (S. epidermidis) at 80 µg/mL, whereas it showed no significant antibacterial activity against Escherichia coli (E. coli). The results of cell viability indicated that ethyl acetate fraction did not show cytotoxicity to B16/F1 cells at 80 µg/mL and showed
EtOAc fractions of Magnolia obovata (M. obovata) Bark extracts were studied for the potential ingredient as a safe and effective whitening cosmetic material. The concentration of active substances honokiol was determined by HPLC. In vitro, the fractions reduced the extracellular and intracellular melanin contents in B16F10 cells in dose dependently and inhibited extracellular melanin secretion (IC 50 = 11.05 µg/mL). The 12.5 µg/mL treatment of maximum concentration effectively inhibited up to about 60% to the amount of extracullular melanin. Also, the 12.5 µg/mL treatment of maximum concentration effectively inhibited up to about 59% to the amount of intracullular melanin (IC 50 = 10.85 µg/mL). The IC 50 value of α-arbutin used as a positive control was 59.99 µg/mL. So, EtOAc fractions of M. obovata Bark extracts showed whitening effect when compared with the non-treatment group. In case of in vivo study, Cosmetic cream with EtOAc fractions of M. obovata Bark extracts was approved by Ethics committee of KDRI
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