The purpose of this study was to investigate the association between sexual intercourse and experience of alcohol, tobacco, and drugs use among adolescents in South Korea. Methods: This study used the data of the Korea Youth Risk Behavior Web-based Survey from 2010 through 2014. The subjects of this study were 367,562 students (Male 187,610, Female 179,952). The subjects' general characteristics and their sexual experiences according to their general characteristics were analyzed using frequency analysis. The relationship between sexual intercourse and the use of alcohol, tobacco, and drugs was analyzed through multiple logistic regression. The analyses were conducted using SPSS 18.0. Results: According to the study, the significant predictors of sexual intercourse were gender, grade, parents' educational level, residence type, economic status, and substance abuse. Adolescents who had used alcohol, tobacco, and drugs were more likely to have had sexual intercourse than their peers who hadn't use the substances. Conclusion: The results suggest that factors that increase the risk of having premature sex should be managed and prevented systematically. Among the factors, in particular, drinking, smoking, and drug use require intensive management.
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