This study aimed to explore the mediating effect of self-care competence on the relationships between uncertainty, self-care competence, and quality of life in patients undergoing hemodialysis. Methods: This study used a descriptive correlation design. Participants were 169 patients who were receiving hemodialysis treatment. Data were collected from November 01, 2017, to June 30, 2018. Measurements included the Patient Assessment of Mishel Uncertainty in Illness Scale, Self-as-Carer Inventory Scale, and the Medical Outcomes Study Short Form-12 (MOS SF-12). The MOS SF-12 comprises the Physical Component Score (PCS) and Mental Component Score (MCS). Data were analyzed using descriptive statistics, Pearson's correlation coefficient analysis, and a three step regression analysis using Baron and Kenny's method for mediation. Results: Mean scores were 2.78±0.03 and 3.96±0.07 for uncertainty and self-care competence, respectively. The mean PCS score was 41.90±17.45) and the mean MCS score was 55.23±15.09. Self-care competence had a partial mediating effect (z=-3.50, p<.001) between uncertainty and PCS as well as an explanatory power of 20%. Self-care competence had a partial mediating effect (z=-2.36, p<.001) between uncertainty and MCS as well as an explanatory power of 11%. Conclusion: To improve the quality of life of hemodialysis patients, developing programs suitable for patients with high uncertainty or programs that increase the self-care competence abilities of the patients should be considered.
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