An economic and environmental synthestic method for 3-chloroindenes from o-(alkynyl)styrenes through tandem reactions including choropalladation/Heck cross coupling in Pd/O 2 system was reported. Taking green dioxygen as sole oxidant and LiCl as chlorine source, 13 functionalized 3-chloroindenes could be synthesized in moderate to high yield without the addition of CuCl 2
A remarkably simple, mild and efficient approach for carbon-carbon bond cleavage of β-keto amides using N-bromobutanimide (NBS) as the bromine source and acetic acid as the catalyst to construct α-dibromosubstituted arylamides is achieved. Moreover, tandem carbon-bromine bond formation, followed by protonation of carbonyl and cleavage of C-C bond in one pot has also been demonstrated. All the reactions were carried out under extremely mild conditions and provided almost quantitative yields of the products.
The α-aminoxylation between α-azoleketones and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) was studied in this paper. Taking Cu(II) salts as catalyst and air as oxidant, a number of alkoxyamines have been synthesized via α-aminoxylation between α-azoleketones and TEMPO in good yields at room temperature. This strategy is highlighted by appealing features such as mild reaction condition, inexpensive catalyst, green oxidant and good yield.
This paper reports a novel intermolecular addition and free radical homolytic reaction for the synthesis of (E)-3-aryloxyacrylate derivatives from alkynoates and phenols using N,N-dimethylformamide (DMF) as the solvent and CuO/CH 3 ONa as the system of promotion. The structures of product were confirmed by IR, 1 H NMR, 13 C NMR and elemental analysis. The results showed that this synthetic route had the advantages of easy-obtained raw materials, simple work-up and high purity product. Keywords alkynoates; phenols; intermolecular addition; (E)-3-aryloxyacrylates为典型反应, 考察了 反应时间、反应温度、溶剂、催化剂和碱的种类和用量 等方面对 3aa 产率的影响, 实验结果如表 1 所示. 从表 1 的数据可知, 在以甲苯、乙腈、1,2-二氯乙烷、1,4-二氧 六环作为溶剂的条件下, 该模型反应不发生(表 1, Entries 1~4). 而当该反应在 100 ℃的条件下进行时, 以 N,N-二甲基甲酰胺(DMF)为溶剂时, 反应 4 h 能以 25% 的收率得到目标化合物 3aa. 接下来, 我们考察了不同 碱对该反应的影响, 研究发现甲醇钠和乙醇钠是比较理
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