A series of N-substituted 2-alkoxyimino-2-cyanoacetamide derivatives were synthesized and their fungicidal activities against cucumber downy mildew were assessed. Our studies of the structure-activity relationships revealed that fungicidal activity was the strongest when the substituents on the acetamide nitrogen were 4, 5-dihydroisoxazole groups. Among the compounds examined, 2-cyano-2-methoxyimino-N-(5, 5-dimethyl-4, 5-dihydroisoxazol-3-yl)acetamide (28) was more active than the original lead compound, cymoxanil.
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