A new class of 4-[(5-aryl-1,3,4-thiadiazol-2-ylamino)methyl]phenol compounds were synthesized via the nucleophilic addition reaction of 5-phenyl-1,3,4-thiadiazol-2-amine with 4-hydroxybenzaldehyde, dehydration and reduction of unsaturated double bond in one-pot. This procedure has the advantages of short reaction time and simple post treatment. The structures of the products were characterized thoroughly by NMR, IR, MS techniques and elemental analysis.
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