The number of elderly cancer patients has been increasing for the past several decades in Japan. The selection of appropriate treatment for elderly patients with cancer is sometimes difficult because of their diverse characteristics and individual differences. In particular, for prefrail cancer patients, who are between fit and frail, the experience of medical staff affects the selection of treatment. Therefore, 10 clinical questions (CQs) have been suggested as provisional clinical opinions for radiotherapy in prefrail elderly colorectal cancer patients by the Radiation Therapy Working Group, comprising seven radiation oncologists, one gastroenterologist, and one gastroenterological surgeon. The present report examines CQ 1 5 as follows. CQ1: What are the difficulties of radiotherapy for prefrail elderly patients with colorectal cancer? ; CQ2: What is the branching point between standard treatment and reduced-intensity treatment with radiotherapy in prefrail elderly patients with colorectal cancer? ; CQ3: What is the appropriate comprehensive geriatric assessment for elderly cancer patients to be treated with radiotherapy? ; CQ4: What should be noted about the adverse events caused by radiotherapy in prefrail elderly patients with colorectal cancer? and CQ5: What should be noted about the adverse events caused by preoperative chemoradiation therapy in prefrail elderly patients with locally advanced rectal cancer?
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