Prothiophos oxon (S-propyl form) and its S-methyl, ethyl and butyl homologs were poor in vitro inhibitors of acetylcholinesterase (AChE), but the S-propyl and butyl oxons were highly insecticidal to houseflies, and inhibited ACNE in vivo. Evidence indicates that such 5alkyl oxons are converted to unstable intermediates by mixed function oxidase system, which have been oxidized on the sulfur and are more reactive with AChE in the case of the S-propyl and butyl oxons, when more hydrolyzable in the case of the S-methyl and ethyl oxons.
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