N-tert-Butoxycarbonyl-methamphetamine (t-BOCMA), a tert-butoxycarbonyl (t-BOC) derivative of methamphetamine (MA), which has recently been reported in several countries, was seized for theˆrst time in Japan in 2017. It deprotected easily in an acidic condition to result in an illicit MA, and recently became a newly designated drug of the Pharmaceutical and Medical Device Act. For drug enforcement, the information of its properties was, therefore, strongly demanded. In this study, we synthesized the t-BOCMA standard, acquired various analytical data, and demonstrated its conversion to MA in high yield in the relatively moderate acidic condition (5 HCl methanol solution, 50°C). Also, the stability of t-BOCMA in simulated gastric juice (0.08 M HCl, 37°C) was explored by using GC/MS. As the result, 19 of t-BOCMA remained even after 120 min incubation, and the T 1/2 was calculated to be 50 min. These suggest that the orally ingested t-BOCMA would be absorbed into blood in some degree without conversion to MA.
In this study, we describe a rapid gas chromatography-tandem mass spectrometry (GC MS/MS) analytical method that allows comprehensive detection and structural elucidation of synthetic cathinone-type designer drugs. Our proposed method consists of three simultaneous analytical procedures: 1) selective detection of the carbonyl group characteristic to each cathinone examined via selected reaction monitoring (SRM); and the determination of both 2) iminium cations and 3) substituted benzoyl cations generated via the a cleavage of their corresponding amines and ketone moieties via product ion scanning, respectively.One peak was detected in the SRM chromatogram for all cathinones examined in procedure 1), as well as the relevant single peaks in the total ion current chro-
本論文の内容は,日本法科学技術学会第20回学術集会発表(平成26年11月)において奨励賞を受賞した.
77法科学技術, 22(2), 77-90(2017) -原著-1 Phenyl 2 ( pyrrolidin 1 yl ) pentan 1 one (a PVP )の種の類縁化合物の ヒトにおける尿中代謝物及び代謝経路 Three analogues of 1 phenyl 2 (pyrrolidin 1 yl)pentan 1 one (a PVP), 1 (4 ‰uorophenyl) 2 (pyrolidin 1 yl)pentan 1 one (4F a PVP), 1 (4 methoxyphenyl) 2 (pyrrolidin 1 yl)pentan 1 one (4MeO a PVP) and 2 (pyrrolidin 1 yl) 1 (thiophen 2 yl)pentan 1 one (a PVT), and their metabolites were determined in users' urine by liquid chromatography-tandem mass spectrometry using newly synthesized authentic standards. The identiˆed metabolites indicated that metabolic pathways of three a PVP analogues include the reduction of the carbonyl group to the corresponding alcohols and the oxidation of the pyrrolidine ring to the corresponding pyrrolidone, and 4MeO a PVP and a PVT have additional metabolic pathways of the O demethylation and the oxidation of thienyl group respectively. The quantitative analyses of the urinary metabolites suggested that the main metabolic pathways of these a pyrrolidinophenones (PPs) derivatives could vary largely depending on the aromatic rings or substituent groups on the aromatic ring of PPs.
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