Abstract:Fifteen pyrazino [2, 3-d] pyridazines were prepared by condensing four kinds of 2, 3-disubstituted pyrazinedicarboxylic anhydrides with hydrazine, methylhydrazine, phenylhydrazine and dimethylhydrazine.The condensates underwent chemical modifications and additional reactions to four kinds of dicyanopyrazines with hydrazine to prepare total thirty-two compounds, which were examined for pesticidal activity. Among them 2-phenyl-5, 8-diacetoxypyrazino [2, 3-d]pyridazine showed protective activity against downy mildew of cucumber.
Eighty-four 3-[(substituted phenylamino)carbonyl]-2-pyrazinecarboxylic acids (3) and the same numbers of N-(substituted phenyl)pyrazine-2, 3-dicarboximides (4) were synthesized starting from various substituted anilines and 2, 3-pyrazinedicarboxylic anhydrides prepared by the condensation of diaminomaleonitrile with 1, 2-diketones, and examined for biological activities. Five compounds of 4 showed certain protective activity against rice bacterial leaf blight and eight compounds of 4 protective activity against rice blast.
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