In this paper, a novel synthetic method for 2-amino-4,5-substituted pyrimidine derivatives was reported, which began from cheap and simple four aromatic aldehydes and three aliphatic aldehydes. 12 compounds of 2-amino-4,5-substituted pyrimidine derivatives were synthesized by four steps with yields of 40%~70%. The structures of terminational compounds were determined by 1 H NMR, 13 C NMR and LC-MS techniques.
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